JOURNAL 2940
Records of Natural Products
Year: 2024 Issue: 1 January-February
p.136 - 142
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Zhihong Luo
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Kai Liu
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Zhen-Zhou Tang
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Liang Peng
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Chenghai Gao
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Chenxi Xia
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Yong-Hong Liu
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Xian-Qiang Chen
GRAPHICAL ABSTRACT
ABSTRACT
One new ascochlorin glycoside (1) and 8 known ascochlorin derivatives (2–9), and ilicicolin H (10) were purified from brittlestar derived fungus Acremonium sp. GXIMD02024. Their structural elucidations were carried out by analyses of 1D and 2D NMR, high resolution mass spectrometry, and CD spectroscopic data and comparison of those with literature data. Compound 1 was a rare fungal polyketide-sesquiterpenoid possessing sugar moiety. The antibacterial and cytotoxicity activities of compounds 1–10 have been performed in vitro. Compounds 1–3, 7, 8, and 10 were measured for their inhibitory effect on a-glucosidase. Compound 1 exhibited poor activity or was inactive, but the detail analysis indicated sugar moiety in 1 maybe play an important role in effect on biological activities.
KEYWORDS- Ascochlorin glycoside
- Acremonium sp
- α-glucosidase inhibitory activity
- marine fungus
