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Two Cationic Indole Alkaloids from Ophiorrhiza japonica and Their Xanthine Oxidase Inhibitory Activity

Short Report

JOURNAL 3235

Records of Natural Products
VOLUME & ISSUE
Year: 2024 Issue: 4 July-August
PAGES
p.446 - 451
DOI ADDRESS
http://doi.org/10.25135/rnp.469.2405.3235
STATISTICS
Viewed 462 times.
AUTHORS
  • Yu He
  • Fan Xu
  • Chun Tian
  • Hong-lian Ai
  • Bao-bao Shi
  • Jikai Liu
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Two previously undescribed cationic indole alkaloids, named ophiorrhines L (1) and M (2), was isolated from the Ophiorrhiza japonica. The structures were elucidated based on spectroscopic data and quantum calculations as well as X-ray crystallographic analysis. Alkaloids 1 and 2 exhibited moderate inhibitory activities on XOD (Xanthine Oxidase) with IC50 values 42.5 and 22.6 µM, respectively.

 KEYWORDS
  • Ophiorrhiza japonica
  • indole alkaloids
  • XO inhibitory effect

SUPPORTING INFORMATION

Supporting Information
Download File A6-469-RNP-2405-3235-SI.pdf (2 MB)