JOURNAL 3250


Records of Natural Products
VOLUME & ISSUE
Year: 2024 Issue: 5 September-October
PAGES
p.514 - 519
STATISTICS
Viewed 352 times.
AUTHORS
  • Kongdech Savaspun
  • Chutamas Thepmalee
  • Hla Myo
  • Apiwan Arinno
  • Anuchit Phanumartwiwath
  • Chanat Aongbangkhen
  • Chatchakorn Eurtivong
  • Siriwat Boonchaisri
  • Padarat Ninjiaranai
  • Pornpat Sam-ang
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A new naturally occurring diarylheptanoid, (1E,4Z,6E)-5-hydroxy-1,7-diphenylhepta-1,4,6-trien-3-one (3), was isolated from the rhizomes of K. elegans along with six known compounds, flavokawain B (1), 5,6-dehydrokawain (2), pinocembrin (4), cardamonin (5), alpinetin (6), and crotepoxide (7), among which compound 6 had not previously been isolated from this plant species. Two chalcones, flavokawain B (1) and cardamonin (5) were active against nitric oxide (NO) radicals released from LPS-induced RAW264.7 macrophages, resulting in 91.58% and 98.68% inhibition of NO production, respectively. Furthermore, compounds 1 and 5 showed superior cytotoxicity against MCF-7 (IC50 = 23.07 and 20.84 mM) and MDA-MB-231 (IC50 = 21.77 and 26.64 mM) cell lines, respectively. In silico molecular modeling studies of the most active compounds 1 and 5 against epidermal growth factor receptors (EGFR) suggested that π–π interactions with residues on the EGFR protein contributed to their anticancer properties. The results suggest that cardamonin (5) could be a promising candidate for further development of anti-inflammatory and anticancer agents.

KEYWORDS
  • Kaempferia elegans
  • flavokawain B
  • cardamonin
  • anti-inflammation
  • human cancer cell
  • molecular modeling

SUPPORTING INFORMATION


Supporting Information
Download File A5-472-RNP-2406-3250-SI.pdf (1.82 MB)