JOURNAL 1643


Records of Natural Products
VOLUME & ISSUE
Available Online: July 30,2020
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.191.20.05.1643
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Xian Wei
  • Yang Tan
  • Yuhe Shi
  • Yuan Yuan
  • Shunmin Li
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A new alkaloid glycoside (1) and six known alkaloids (27) were isolated from the stems of Zanthoxylum dissitum Hemsl.. The structure of compound 1 was resolved by spectrum data, including MS, IR, UV, and MS. All compounds obtained in this research were evaluated for their inhibitions against NO release from LPS-activated RAW264.7 macrophages. Compounds 1-3, 6 and 7 showed significant inhibition activities with IC50 values of 26.12±0.81, 8.41±0.23, 13.75±0.54, 6.97±0.77, and 5.78±0.42 μM, respectively.

 

KEYWORDS
  • Zanthoxylum dissitum Hemsl.
  • alkaloid
  • macrophages
  • NO

SUPPORTING INFORMATION


Scifinder new compound search report
Download File Scifinder new compound search report.pdf (11.62 KB)
Supporting Information
Download File 191-RNP-2005-1643-SI.pdf (1.95 MB)