Benzodiazepine Derivatives from Marine-Derived Streptomyces cacaoi 14CM034

Short Report

JOURNAL 1766

Records of Natural Products
VOLUME & ISSUE
Available Online: October 19,2020
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.203.20.08.1766
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 166 times.
AUTHORS
  • Semiha Çetinel
  • Melis Küçüksolak
  • Ataç Uzel
  • Erdal Bedir
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

7-methoxy-8-hydroxy cycloanthranilylproline (2), a new natural product with pyrrolobenzodiazepine (PBD) framework, was isolated from marine-derived actinobacterium Streptomyces cacaoi 14CM034, together with cycloanthranilylproline (1). Structural elucidation of the compounds was based on FTIR, 1D- (1H and 13C NMR), 2D-NMR (COSY, HMBC and NOESY) and HR-MS analyses. Compounds 1 and 2 exhibited notable antimicrobial activity. The presence of PBD derivatives in S. cacaoi was first demonstrated with this study.

 KEYWORDS
  • Marine actinobacterium
  • Streptomyces cacaoi
  • Benzodiazepine
  • Antimicrobial activity
  • Antibiotics

SUPPORTING INFORMATION

Supporting Information
Download File 203-RNP-2008-1766-SI.pdf (1.95 MB)