JOURNAL


Records of Natural Products
VOLUME & ISSUE
Available Online: November 28,2018
PAGES
p.1 - 9
DOI ADDRESS
http://doi.org/10.25135/rnp.111.18.09.897
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Pengxiang Lai
  • Xiao-Dan Su
  • Yang Gao
  • Yingxin Xiang
  • Pengxiang Lai
  • Xiang Xing
  • 1 - shandong university
  • 2 - Shandong University
  • 3 - Shandong University
  • 4 - Shandong University
  • 5 - Shandong University
  • 6 - Shandong University
PDF OF ARTICLE

ABSTRACT


Abstract:  The present study investigated the chemical composition of the essential oil obtained from the aerial parts of Aristolochia fordiana Hemsl (AF-EO) using GC-FID and GC-MS, and evaluated the in vitro biological activities of the essential oil. Forty-nine compounds representing 99.6% of the total oil were characterized. The main constituents were identified as β-Chamigrene (17.0%), β-Caryophyllene (11.1%), α-Bulnesene (11.0%) and β-Pinene (10.2%). Furthermore, the antibacterial activity of the essential oil of A. fordiana was studied using disc diffusion and micro-broth dilution assays. AF-EO exhibited an excellent antibacterial activity against Staphylococcus aureus and Bacillus subtilis with MIC values below 100 μg/mL. Besides, the results of MTT assays indicated that the essential oil exhibited a moderate cytotoxic activity on HepG2 (liver hepatocellular cells) and MCF-7 (human breast adenocarcinoma cells) cell lines. However, the AF-EO showed a weak antioxidant activity in DPPH, ABTS and FRAP assays.

KEYWORDS
  • Aristolochia fordiana Hemsl
  • essential oil
  • antibacterial activity
  • cytotoxic activity
  • antioxidant activity