JOURNAL 3321
Records of Natural Products
Available Online: January 04,2025
p.1 - 6
http://doi.org/10.25135/rnp.491.2409.3321 (DOI number will be activated after the manuscript has been available in an issue.)
Viewed 178 times.
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José L. Salvador-Hernández
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Luis J. Calvillo-Carranza
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Rosa E. del Río
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Joel E. López-Meza
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Alejandra Ochoa-Zarzosa
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Julio C. Ontiveros-Rodríguez
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Carlos M. Cerda-García-Rojas
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Hugo A. García-Gutiérrez
GRAPHICAL ABSTRACT
ABSTRACT
The dichloromethane (DCM) and ethyl acetate (EtOAc) extracts of C. caeruleus yielded nine known compounds, including an A-nor-lupane triterpenoid identified as gouanic acid B (1). Additionally, its acetyl derivative, acetylgouanic acid B (2), is reported here for the first time as a natural product. Furthermore, we tested the bioactivity of natural products 1 and 2 and their dimethyl ester derivatives 3 and 4 against cancer cell lines MCF-7, A549, HeLa, and K562. Among these, compounds 1 (IC50 = 36.4 ± 4.0 μM), 2 (IC50 = 21.6 ± 4.3 μM), and 4 (IC50 = 33.0 ± 2.0 μM) demonstrated moderate to good activity against the K562 cell line while maintaining a satisfactory survival rate in non-cancerous bMEC cells. Notably, the natural triterpenes 1 and 2 and derivative 4 showed remarkable outcomes in cytotoxicity tests due to their specificity against K562 leukemia cells.
KEYWORDS- Ceanothus caeruleus
- triterpenoid
- bioactive compounds
- cytotoxicity activity
- non-cancerous cell line
