JOURNAL


Records of Natural Products
VOLUME & ISSUE
Available Online: January 19,2019
PAGES
p.1 - 15
DOI ADDRESS
http://doi.org/10.25135/rnp.108.18.10.984
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Zahra Eskandari
  • Fatemeh Bahadori
  • Melda Altikatoglu
  • Vildan Betul Yenigun
  • Abdurrahim Kocyigit
  • Hayat Onyuksel
  • 1 - Yildiz Technical University
  • 2 - Bezmialem Vakif University
  • 3 - Yildiz Technical University
  • 4 - Bezmialem Vakif University
  • 5 - Bezmialem Vakif University
  • 6 - University of Illinois at Chicago
PDF OF ARTICLE

ABSTRACT


This study aims to investigate the effects of co-administration of nano-Curcumin on anticancer effect of nano-Pirarubicin considering the fact that the clinical use of Pirarubicin and other anthracyclines has been limited by development of multidrug resistance (MDR) and based on previous data which have shown that Curcumin can down-regulate MDR proteins and suppress the activity of Nuclear factor-kappa B (NF-κB) a protein involved in chemoresistance. Nano micellar formulations of both Curcumin and Pirarubicin were separately synthesized using 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-[poly(ethylene glycol); PEG MW 2,000] (DSPE-PEG2000). The produced sterically stabilized micelles (SSM) are very well known drug delivery systems in terms of their enhanced efficacy and good toxicity profile. We measured the differences of NF-κB levels in two different situations: when Pirarubicin is used alone and when it is co-administered with Curcumin. This study showed that co-administration of SSM-Curcumin (CSSM) and SSM-Pirarubicin (PSSM) with size of 12.81 nm enhances the efficacy of Pirarubicin by suppressing P65, an NF-κB subunit. Furthermore, we showed that SSM is able to successfully enhance water solubility and therapeutic stability of curcumin for using as a complementary agent.

KEYWORDS
  • Curcumin
  • pirarubicin
  • nanoparticles
  • NF-κB
  • breast cancer

SUPPORTING INFORMATION


Supporting Information
Download File 108-RNP-1810-984-SI.pdf (2.01 MB)