JOURNAL 1573


Records of Natural Products
VOLUME & ISSUE
Available Online: May 27,2020
PAGES
p.1 - 10
DOI ADDRESS
http://doi.org/10.25135/rnp.184.20.03.1573
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Chiyeon Lim
  • Chang-Hyun Kim
  • Se-Hyun Lim
  • Suin Cho
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Salvianolic acid B (SAB) is one of main components of the dried roots and rhizomes of Salvia miltiorrhiza Bunge (RSM), which is widely used as a medicinal herb in East-Asia. According to traditional Korean medicine, RSM promotes blood flow, and thus, we investigated the effects of administering SAB after ischemia/reperfusion (I/R)-induced brain injury in a mouse model. I/R-induced brain injury was induced by middle cerebral artery occlusion (MCAO) for 2 h. SAB was orally administered to mice twice after 3 and 6 h of occlusion at 5, 15, or 45 mg/kg body weight. Administration of SAB at 45 mg/kg significantly reduced infarct volumes and edema indices and suppressed interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), and reactive oxygen species (ROS) levels in brain ipsilateral hemispheres. SAB also down-regulated Mn-SOD protein expression in affected brain tissues after I/R-induced brain injury. Our results indicate the neuro-protective effects of salvianolic acid B are due to its anti-inflammatory effect mediated by intra-cellular superoxide scavenging..

KEYWORDS
  • Salvianolic acid B
  • Salvia miltiorrhiza
  • ischemia/reperfusion injuryi
  • nflammationb
  • rain edema

SUPPORTING INFORMATION


Supporting Information
Download File 184-RNP-2003-1573-SI.pdf (277.69 KB)