Two New Compounds from Arctium lappa Roots

Original Article

JOURNAL 3187

Records of Natural Products
VOLUME & ISSUE
Available Online: September 15,2024
PAGES
p.1 - 9
DOI ADDRESS
http://doi.org/10.25135/rnp.474.2404.3187
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Qingyu Yang
  • Jun Chi
  • Weijin Zhang
  • Lingxia Zhang
  • Zhimin Wang
  • Liping Dai
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A new caffeoylquinic acid, 1, 5-di-O-caffeoyl-3-O-(1-O-methoxy-2-O-caffeoyl-4-maloyl)-quinic acid (1), and a new 5-hydroxymethylfurfural dimer, 5-(((2-methoxymethyl) furan-5-methanol) methyl) furan-2-carbaldehyde (2), were discovered from Arctium lappa roots. A comprehensive HRMS, UV, IR, 1D and 2D NMR techniques were used for structural identification. These two compounds had Nitric Oxide (NO) inhibitory activity in lipopolysaccharide (LPS)-stimulated RAW 264.7 inflammatory cell in a dose-dependent manner.

 

 KEYWORDS
  • Arctium lappa roots
  • caffeoylquinic acid
  • 5-hydroxymethylfurfural derivative
  • anti-inflammatory activity

SUPPORTING INFORMATION

Two new compounds from Arctium lappa roots
Download File Revised supporting information.doc (81.44 MB)