JOURNAL


Records of Natural Products
VOLUME & ISSUE
Available Online: April 29,2019
PAGES
p.1 - 7
DOI ADDRESS
http://doi.org/10.25135/rnp.126.19.03.1205
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Qin Ren
  • Zhenxing Zou
  • Yang Liu
  • Xi Chen
  • Kangping Xu
  • Guishan Tan
  • 1 - Xiangya Hospital of Central South University, Changsha 410008, PR China
  • 2 - Xiangya School of Pharmaceutical Sciences, Central South University
  • 3 - Xiangya Hospital of Central South University, Changsha 410008, PR China
  • 4 - Xiangya School of Pharmaceutical Sciences, Central South University
  • 5 - Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China
  • 6 - Central South University
PDF OF ARTICLE

ABSTRACT


Two new lignans, named lycojaponicumoside A (1) and B (2), together with four known compounds (3˗6) were isolated from the n-BuOH extract of Lycopodium japonicum. Their structures were elucidated on the basis of extensive spectroscopic methods, especially various NMR techniques, HRESIMS and circular dichroism (CD). The absolute configuration of compound 1 was established by the calculation of electronic circular dichroism (ECD) curves. All of the compounds were evaluated for their cytotoxic activities against A549 and HepG2 human cancer cell lines, but those compounds did not exhibit cytotoxicity.

KEYWORDS
  • Lycopodium japonicum
  • lignans
  • ECD calculation

SUPPORTING INFORMATION


Supporting Information
Download File 126-RNP-1903-1205-SI.pdf (1.65 MB)