Electrochemical studies of regorafenib in non-aqueous media

Original Article

JOURNAL 1104

Bioorganic and Medicinal Chemistry Reports

VOLUME & ISSUE

Year: 2018 Issue: 1 January-December

PAGES

p.22 - 28

DOI ADDRESS

http://doi.org/10.25135/bmcr.10.18.12.110486

STATISTICS

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AUTHORS

Züleyha Kudaş

GRAPHICAL ABSTRACT

ABSTRACT

A novel tyrosine kinase inhibitor, regorafenib was electrochemically studied using a GC disc electrode in non-aqueous media. A well-resolved, irreversible, diffusion-controlled oxidation peak was obtained at 1.55 V in acetonitrile solution containing 0.1 M TBAClO4. Experimental conditions such as scan rate, indicate that two electrons play a role in the electrochemical oxidation of regorafenib. The recommended method was successfully applied to the determination of regorafenib in drug capsules.

KEYWORDS

Regorafenib
cyclic voltammetry
electrochemical oxidation