Records of Natural Products

A scientific open access journal in the field of natural products.
Editor-in-Chief: Gülaçtı Topçu
Editor-in-Chief: Ahmet C Goren

LATEST ARTICLES

Review Article

Chemical Constituents and Pharmacological Activities of the Genus Nageia

Rec. Nat. Prod. (2024) in press ; 1 - 22
by Lijun Zou , Xiao Chen , Jialin Zhang , Qi Sun , Shuoshuo Fu , Sha Yang , Huiyou Xu , Jian Zhou and Lin Ni

There are seven species in the genus Nageia, a member of the Podocarpaceae family; five are found in China. They are primarily found in eastern and southern Asia, close to the equator at the 30th parallel north and south, and in coastal mountainous areas and islands in the western Pacific. These herbs are extremely valuable for medicinal purposes. The three species of Nageia that are the subject of most current research on their chemical composition and pharmacological properties are N. nagi, N. fleuryi, and N. wallichiana. There are currently 232 known chemical components, which include steroids, flavonoids, sesquiterpenoids, and diterpenoids. Of these, 86 diterpenoid dilactones comprise most of the chemical components, and only plants of the Nageia genus contain C-ring decarbonized diterpenoid dilactones. These plants exhibit promising pharmacological activities such as anti-tumor, antioxidant, antibacterial, and anti-inflammatory properties. For the first time, an in-depth and systematic evaluation of the chemical constituents and pharmacological properties of plants in the Nageia genus is presented in the this article. This theoretical framework will help in the future investigation and development of medicinal resources and active ingredients within the genus.

DOI
http://doi.org/10.25135/rnp.435.2311.2979
Keywords
Nageia diterpenoids nagilactones antitumor antioxidants bacteriostatic
Available online: February 21, 2024
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Original Article

A New Diphenyl Ether Derivative from an Endolichenic Fungus, Preussia africana

Rec. Nat. Prod. (2024) in press ; 1 - 6
by Jinjie Liu , Miaomiao Xiong , Xinyi Zhai , Jinxiu Zhang , Zhuang Li and Jianhua Lv

A new diphenyl ether derivative, namely barceloneic lactone D (1), along with five known compounds (2-6) were isolated from the solid cultures of an endolichenic fungus, Preussia africana. The structure of new compound was elucidated by HR-ESI-MS, 1D and 2D NMR spectroscopy. All the isolates were evaluated for their antifungal activities. All compounds showed definite inhibitory activities with inhibition rate ranging from 9.2% to 79.2%.

DOI
http://doi.org/10.25135/rnp.446-2401.3027
Keywords
Preussia africana diphenyl ether antifungal
Available online: February 21, 2024
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Original Article

Identification of Diverse Sesquiterpenoids from Eupatorium adenophorum

Rec. Nat. Prod. (2024) in press ; 1 - 8
by Wen-jie Gu , Jia-hui Luo , Yong-Xun Yang and Hao Geng

Ten sesquiterpenoids (1-10), including two new compounds 1 and 2, were isolated with the use of several chromatographic methods from the above-ground tissues of Eupatorium adenophorum Spreng. Comprehensive spectroscopic studies, such as single-crystal X-ray diffraction, 1D, 2D-NMR, and HRMS, were used to characterize their structures. The cytotoxic and anti-inflammatory actions and properties of the new compounds 1 and 2 were examined and briefly discussed.

DOI
http://doi.org/10.25135/rnp.445.2401.3018
Keywords
Chemical structures compositae sesquiterpenoids Eupatorium adenophorum
Available online: February 21, 2024
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Short Report

Phytosteroids from Roots of Psammosilene tunicoides W.C.Wu et C.Y.Wu

Rec. Nat. Prod. (2024) in press ; 1 - 6
by Yanhong Li , Ziliang Wang , Hongrui Li , Yuxiao Li , Kexin Nie , Xiuxia Yang , Xishan Bai and Xiangzhong Huang

To explore structurally and pharmacologically interesting secondary metabolites from Psammosilene tunicoides, a crude extract of this plant was investigated, leading to the isolation of a new phytoecdysteroid, furoecdysterone (1) and four known phytosteroid compounds, ecdysterone (2), 22-deoxyecdysterone (3), β-sitosteryl d-glucoside (4), and b-sitosterol (5). Their structures were identified based on a detailed analysis of NMR spectra and MS data. Those compounds, except for 2, showed moderate NO inhibition activities on lipopolysaccharide (LPS)-induced release in RAW 264.7 cells.

DOI
http://doi.org/10.25135/rnp.444.2312.2991
Keywords
Psammosilene tunicoides phytoecdysteroid Nitric oxide inhibition activity RAW 264.7 cells
Available online: February 21, 2024
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© ACG Publications. All rights reserved.