Records of Natural Products

A scientific open access journal in the field of natural products.
Editor-in-Chief: Gülaçtı Topçu
Editor-in-Chief: Ahmet C Goren

LATEST ARTICLES

Short Report

A New Acyclic Compound from the Medicinal Plant Tinospora sinensis

Rec. Nat. Prod. (2025) in press ; 1 - 5
by Mengying Zhang and Lijing Cai

In this study, chemical investigation of the aerial parts of the medicinal plant Tinospora sinensis yielded five compounds (1-5), including a new acyclic compound (1) and four known compounds (2-5). Their structures were determined by extensive analysis of the spectroscopic data, including 1D (1H and 13C NMR) and 2D NMR data (HSQC, COSY, and HMBC). Compounds 3-5 were identified to be stearic acid (3), abscisic acid (4), and blumenol A (5) based on comparisons of the NMR data with those reported in the literature. The NMR data for 2-hydroxy methyl stearate (2) were reported for the first time in CDCl3 in this study. The compounds were evaluated for their antitumor potential against A549 cell line, while all were inactive (25 mM). Besides, compound 1 demonstrated marginal inhibition (19.35%) of LPS-induced NO production in RAW 264.7 cells (50 mM).

DOI
http://doi.org/10.25135/rnp.530.2505.3536
Keywords
Tinospora sinensis acyclic compound NMR
Available online: July 26, 2025
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Short Report

Phytochemical Characterization, Antifungal Activity and Docking Investigation of The Isolated Compounds from Lippia callicarpifolia

Rec. Nat. Prod. (2025) in press ; 1 - 6
by Ana K. Villagómez-Guzmán , Ana M. García-Bores , Israel Valencia , Miriam Arlette López-Pérez , Edgar Antonio Estrella-Parra , José G. Avila-Acevedo and Tzasna Hernández-Delgado

Bioassay-guided fractionation of extracts of aerial parts from Lippia callicarpifolia usingvia chromatographic techniques led to the isolation of two D:C-friedours-7-ene compounds, namely D:C-3-oxo-friedours-7-en-28-oic acid (1) and a new callicarpifolic acid (2). Furthermore, additional known compounds, β-sitosterol glucoside (3) and genkwanin (4) were also identified. The structures of the natural products were established by 1D and 2D NMR, IR, and spectrometric analysisanalyses. In the antifungal assays, Fusarium sporotrichioides NRLL was sensitive to compounds 1 and 4 in the concentration range of 0.250-–1 mg/mL. The docking investigation revealed high inhibition of the trichodiene synthase enzyme by compound 4.

DOI
http://doi.org/10.25135/rnp.535.2502.3432
Keywords
Lippia callicarpifolia Fusarium sporotrichioides genkwanin callicarpifolic acid
Available online: July 26, 2025
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Original Article

Isolation and Identification of Diterpenoids from Euphorbia helioscopia and Their Anti-inflammatory Activities

Rec. Nat. Prod. (2025) in press ; 1 - 8
by Liping Dai , Jinke Zheng , Jun Chi , Bin Cao and Huili Li

Phytochemical investigation of 70% ethanol extract of Euphorbia helioscopia led to eight diterpenoids, including four jatrophane-type (14), three abietane-type (57) and one lathyrane-type (8). Among them, (5E,11E)-3β-benzoyloxy-7β,14α,15β-trihydroxyjatropha-9-one (1) was a new jatrophane diterpenoid. An extensive array of spectral analyses, including HR-ESI-MS, IR, UV, 1D and 2D NMR, as well as quantum chemical calculations of ECD curve, were utilized for their structural elucidation. Bioassay results showed that compounds 23 and 68 could significantly inhibit NO release on LPS-induced RAW 264.7 cells, especially for jatrophane diterpenoid 3 and abietane diterpenoid 8 that showed stronger activities with the IC50 values of 9.16 ± 0.70 and 5.74 ± 0.27 μM.

DOI
http://doi.org/10.25135/rnp.533.2502.3446
Keywords
Euphorbia helioscopia diterpenoids anti-inflammatory
Available online: July 26, 2025
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Short Report

A New Lignan with Potential Anti-inflammatory Activity from Notopterygium incisum

Rec. Nat. Prod. (2025) in press ; 1 - 6
by Li-lian Zhao , Su Hu , Xin-Yu Li , Yun Deng , Li-jun Huang and Dale Guo

NNotopterygium incisum is widely used in clinical practice because of its complex chemical composition and remarkable pharmacological effects. In this study, a previously undescribed lignan (1) was isolated from N. incisum. Its structure was evaluated through examinations of the NMR, HREIMS data and ECD calculation. Compound 1 demonstrated significant anti-inflammatory potential by inhibiting the secretion of nitric oxide (NO) in lipopolysaccharide (LPS)-induced macrophages, with an IC50 value of 3.57 μM.

DOI
http://doi.org/10.25135/rnp.2505.3518
Keywords
Notopterygium incisum lignan anti-inflammatory activity
Available online: July 14, 2025
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