Records of Natural Products

A scientific open access journal in the field of natural products.
Editor-in-Chief: Gülaçtı Topçu
Co-Editor-in-Chief: Ahmet C Goren

LATEST ARTICLES

Short Report

Trichonafurin A: a New γ-Lactone Compound from the Marine-Derived Fungus Trichoderma atroviride ZW-7

Rec. Nat. Prod. (2023) in press ; 1 - 5
by Lu-Di Zhai , Wei Gao , Li-Ting Liu , Ke Zhang and De-Liang Zhang

A new γ-lactone compound, trichonafurin A (1), was obtained from the culture of Trichoderma atroviride ZW-7, an endophyte of the marine brown alga Sargassum thunbergii. Its structure was unambiguously assigned by detailed interpretation of 1D/2D NMR and HRESIMS data. Trichonafurin A (1) exhibited moderate cytotoxicity against HeLa and HepG2 cell lines with IC50 values of 20.2 and 32.1 μM, respectively.

DOI
http://doi.org/10.25135/rnp.388.2302.2714
Keywords
Trichoderma atroviride secondary metabolites cytotoxic activity
Available online: March 22, 2023
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Short Report

A New Ingenane Diterpenoid from Euphorbia jolkinii

Rec. Nat. Prod. (2023) in press ; 1 - 5
by Wen Xing Liu , Ying-jun Zhang , Min Zhou and Ping Zhao

 A new ingenane diterpenoid, named ingenol-20-laurate (1), and two known analogues (ingenol-20-palmitate (2), ingenol-20-pentadecanoate (3)) and an ent-abietane diterpenoid (euphopilolide, 4) were isolated from the whole plants of Euphorbia jolkinii. The structure of compound 1 was elucidated by HRESIMS and 2D NMR methods. The cytotoxicities of compound 1 against SMMC-7721, MDA-MB-231, and SW480 cell lines were 27.22±0.58, 17.69±0.29 and 16.19±0.77 μM, respectively.

DOI
http://doi.org/10.25135/rnp.384.2301.2685
Keywords
Euphorbia jolkinii diterpenoids cytotoxicities
Available online: March 22, 2023
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Short Report

A New Megastigmane Glycoside and Anti-Inflammatory Bibenzyls from the Stems of Dendrobium henanense

Rec. Nat. Prod. (2023) in press ; 1 - 5
by Siyu Wu , Shihui Qin , Chuihao Kong , Renzhong Wang , Deling Wu and Fengqing Xu

A new megastigmane glycoside, namely (9S)-O-β-D-glucopyranosyl-2,5-megastigmen-4-one (1), along with seven known bibenzyls (2-8) were isolated from the aerial stems of Dendrobium henanense. Their structures were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-, 2D-NMR and HR-MS. The anti-inflammatory activities of compounds 1-8 evaluated its anti-inflammatory activity by inhibiting the production of inflammatory cytokines such as NO, TNF-α and IL-6 in LPS-stimulated RAW264.7 macrophages. Compounds 3, 4, 6-8 exhibited moderated anti-inflammatory activity with IC50 values of below 100 µΜ.

DOI
http://doi.org/10.25135/rnp.382.2211.2626
Keywords
Dendrobium henanense megastigmane glycoside anti-inflammatory RAW264.7 macrophages
Available online: March 10, 2023
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Original Article

A Novel Phenanthrene and An Undescribed Alkaloid from the Roots of Stephania tetrandra

Rec. Nat. Prod. (2023) in press ; 1 - 6
by Renzhong Wang , Siyu Wu , Jinye Xu , Fengqing Xu and Deling Wu

A novel phenanthrene compound, diphenanthrin (1), and an undescribed alkaloid compound, N-chloromethylstephenanthrine (2), together with two known compounds (3-4) were isolated from the EtOH extract of the roots of Stephania tetrandra. Their structures were elucidated by 1D and 2D NMR, mass spectroscopy and comparison of NMR data with those of known compounds. In anti-inflammatory assay,  compounds 3 and 4 showed the inhibitory effects on NO production, with IC50 values of 41.51 ± 0.20 and 23.87 ± 2.12 μM.

DOI
http://doi.org/10.25135/rnp.381.2212.2663
Keywords
Stephania tetrandra phenanthrene alkaloid anti-inflammatory
Available online: March 04, 2023
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