Records of Natural Products

A scientific open access journal in the field of natural products.
Editor-in-Chief: Gülaçtı Topçu
Co-Editor-in-Chief: Ahmet C Goren

LATEST ARTICLES

Original Article

Chemical Constituents from the Whole Plant of Pachysandra terminalis

Rec. Nat. Prod. (2022) in press ; 1 - 9
by Chao Ding , Yuze Li , Ying Wu , Yu Sun , Fengrui Wang , Huawei Zhang , Yi Jiang , Dongdong Zhang and Xiaomei Song

Two new compounds, butyl(Z)-3-((3R,4R)-5-(hydroxymethyl)-3,4-dimethyl-3,4-dihydro- 2H-pyran-6-yl)acrylate (1) and (2Z,4S)-4,5-dihydroxy-3,4-dimethylpent-2-enoic acid (2) along with seven known ones, stigmast-5,28(29)-dien-3β-ol (3), β-sitosterol (4), carotene (5), fraxetin (6), p-coumaric acid (7), cis-p-hydroxycinnamic acid (8), ferulic acid (9) were obtained from the whole plant of Pachysandra terminalis. The structures of these compounds were elucidated by comprehensive spectroscopic methods including 1D, 2D NMR, MS, IR and ECD data analysis. Notably, compounds 3 and 5~8 were isolated from genus Pachysandra for the first time. Moreover, compounds 1~3 and 6~8 were tested their cytotoxic activities against three cancer cells, however, only compound 1 showed inhibitory effect in SW620 cells with IC50 value of 47.7 μM.

DOI
http://doi.org/10.25135/rnp.346.2205.2465
Keywords
Pachysandra terminalis chemical composition isolation and purification steroids fatty acids
Available online: August 06, 2022
DETAILS DOWNLOAD PDF
© ACG Publications. All rights reserved.
Short Report

Polyketides and Alkaloids from the Deep-Sea-Derived Fungus Aspergillus fumigatus CBC18132

Rec. Nat. Prod. (2022) in press ; 1 - 6
by Yu Liu , Fan Yang , Xiaoqian Zhang , Ying Qiao , Wei Xu , Qin Li and Zhongbin Cheng

Abstract: The fungal strain Aspergillus fumigatus CBC18132, isolated from deep-sea sediment, was investigated for secondary metabolites. Fermentation on rice medium followed by chromatographic separation led to the isolation of three polyketides (13) and nine alkaloids (413). The structures were determined by analyses of spectroscopic data (1H and 13C NMR, and MS data). The absolute configuration of the anthraquinone-derivative trypacidin was resolved for the first time by a combination of ECD and specific rotation calculation. All isolated compounds were inactive toward the -glucosidase at the initial concentration of 2 mM.

DOI
http://doi.org/10.25135/rnp.348.2204.2447
Keywords
Aspergillus fumigatus trypacidin absolute configuration
Available online: August 06, 2022
DETAILS DOWNLOAD PDF
© ACG Publications. All rights reserved.
Original Article

Tigliane-Type Diterpenoids from the Seeds of Croton tiglium

Rec. Nat. Prod. (2022) in press ; 1 - 6
by Lijuan Zhang , Fei Li , Jianyong Zhu and Qian Niu

A new tigliane-type diterpenoid (1) and three known analogues (2-4) were isolated from the seeds of Croton tiglium. Extensive spectroscopic analyses, especially the 2D NMR experiments were used to determine their structures. The absolute configuration of 1 was defined by single-crystal X-ray diffraction data. The cytotoxicity 1-4 was evaluated against melanoma cell line A375, and the results showed that compounds 1, 3, and 4 exhibited certain cytotoxicities.

DOI
http://doi.org/10.25135/rnp.344.2205.2455
Keywords
Croton tiglium tigliane-type diterpenoid cytotoxicity
Available online: July 29, 2022
DETAILS DOWNLOAD PDF
© ACG Publications. All rights reserved.
Original Article

The First Example of Di--Methane Rearrangement in Nature: Cephalotanols A and B, Two Novel Rearranged Norlignan Glycosides from Cephalotaxus fortunei Hook

Rec. Nat. Prod. (2022) in press ; 1 - 9
by Xiaoyan Xie , Qingqing Zhou , Yanting Zhou and Jinbiao Xu

A pair of unique diastereoisomers of norlignan glycosides named cephalotanols A (1) and B (2), together with two known compounds, have been isolated from the twigs and leaves of Cephalotaxus fortunei Hook. Their structures were elucidated by using a combination of spectroscopic techniques and comparison of experimental and calculated electronic circular dichroism (ECD) data. To our knowledge, cephalotanols A and B represent the first rearranged norlignan glycosides with diphenylvinylcyclopropane core found in natural sources, of which biosynthetic pathways originating from co-occurring precursors 3S-4'-O-β-D-glucopyranosylhinokiresinol (3) and 3S-4''-O-β-D-glucopyranosylhinokiresinol (4) via di-π-methane rearrangement is proposed.

DOI
http://doi.org/10.25135/rnp.345.2205.2461
Keywords
Cephalotaxus fortune norlignan diphenylvinylcyclopropane structural elucidation di-π-methane rearrangement
Available online: July 28, 2022
DETAILS DOWNLOAD PDF
© ACG Publications. All rights reserved.