Records of Natural Products

A scientific open access journal in the field of natural products.
Editor-in-Chief: Gülaçtı Topçu
Editor-in-Chief: Ahmet C Goren

LATEST ARTICLES

Review Article

Schisantherin B: Review of Its Preparation, Biological Activities, Pharmacokinetics Analysis and Content Determination

Rec. Nat. Prod. (2024) in press ; 1 - 16
by Ying Wu , Chao Ding , Linwei Dan , Jiamei Tang , Jiayi Zhang , Yuze Li , Xiaomei Song and Dongdong Zhang
Schisandra chinensis (S. chinensis) is the dried mature fruit of Schisandra chinensis (Turcz.) Baill. Its primary active elements include polysaccharides, lignans, and other substances, and it is essential for neuroprotection, hepatoprotection, anti-inflammatory, antioxidant, and other functions. One of the components of lignan, schisantherin B (STB), is commonly extracted using ultrasonic extraction or a combination of ultrasonic and microwave techniques. The macroporous resin method is used to purify the extract at first. Pharmacological studies have shown that it has hepatoprotective, antitumor, and neuroprotective effects, among which hepatoprotective effects are more prominent, mainly by reducing the activity of intrahepatic ghrelin transaminase and improving liver damage. In addition, the pharmacokinetic analysis demonstrated that STB was well absorbed in vivo and was mainly in the form of passive transport in the gastrointestinal tract. The metabolic pathways in rats were also relatively diverse. At the same time, its content is related to the herb's traits, processing, storage methods, distribution, and other aspects. Therefore, the preparation, pharmacological effects, pharmacokinetic characteristics, and content determination of STB will be summarized, aiming to improve its knowledge system and provide a theoretical basis for subsequent more in-depth studies.
DOI
http://doi.org/10.25135/rnp.462.2404.3192
Keywords
Schisandra chinensis Schisantherin B Preparation Pharmacological effects Pharmacokinetic Content determination
Available online: June 10, 2024
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Short Report

New sulfureous diketopiperazine from roots of Moringa oleifera

Rec. Nat. Prod. (2024) in press ; 1 - 5
by Tran Van Hien , Nguyen Thi Hong Anh , Nguyen Thi Luyen , Le Thi Phuong Quynh , Nguyen Thi Thuy Hang , Nguyen Thi Thu Thuy , Do Hoang Giang and Nguyen Tien Dat

Phytochemical investigation of the roots of Moringa oleifera led to the isolation of a new sulfureous diketopiperazine, 7-epi lasiodipline D (1) together with its diastereomer, lasiodipline D (2), and two other known compounds. Structures of the isolated compounds were elucidated by HRESIMS, NMR, and ECD data. For the first time, sulfureous diketopiperazine derivatives (1-3) were obtained from the roots of M. oleifera.

DOI
http://doi.org/10.25135/rnp.463.2403.3158
Keywords
Moringa oleifera Moringaceae diketopiperazine 7-epi lasiodipline D lasiodipline D lasiodipline C
Available online: June 10, 2024
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Short Report

Calkbisabenacid, A New Bisabolane Sesquiterpenoid from the Leaves of Callicarpa kwangtungensis

Rec. Nat. Prod. (2024) in press ; 1 - 5
by Yongbang Zhu , Xuan Zheng , Weiqiang Fei and Daoxian Ding

A new bisabolane sesquiterpenoid, named calkbisabenacid (1), was isolated from the leaves of Callicarpa kwangtungensis, along with four known compounds: 5-O-coumaroylquinic acid (2), kaempferol (3), and soyasapogenol B (4). The structure of compound 1 was determined by 1H NMR, 13C NMR, COSY, HSQC, and HMBC spectra, in combination with the HRESIMS data. The absolute configuration of C-1 in compound 1 was determined by comparing the experimental ECD spectrum with the calculated ECD spectra of the two possible stereoisomers. The known compounds were identified by comparing their NMR data with those reported in the literature. Compound 4 was isolated from this species for the first time. None of these compounds demonstrated any inhibitory effects against Staphylococcus aureus ATCC 25923.

DOI
http://doi.org/10.25135/rnp.461.2404-3196
Keywords
Calkbisabenacid Sesquiterpene Callicarpa kwangtungensis
Available online: May 30, 2024
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Short Report

Chemical Components of the Extracts and Essential Oil of Sanguisorba minor Scop. subspecies muricata (Spach) Briq.

Rec. Nat. Prod. (2024) in press ; 1 - 6
by Ana Barjaktarevic , Tijana Kokeric , Snezana Cupara , Marija D. Ilic , Milja Zivkovic , Ksenija Obradovic and Vesna Stankov Jovanovic

The aim of this study is to investigate the chemical composition of ethanol, acetone extracts and essential oil of the roots and aerial parts of Sanguisorba minor subsp. muricata. Flavonoids and phenolic acids were identified as the main components in the studied extracts herein. Rutin and quercetin-3-sophoroside were found to be dominant flavonoids in both extracts. Although it was observed that the determined chemical compositions of the essential oil obtained from the aerial parts and roots of the plant species were quite different from the data obtained by Headspace measurement, as expected, the essential oils obtained from the species were found to be rich in mainly monoterpene hydrocarbons and oxygenated monoterpenes. While salicylaldehyde, carvacrol and linalool were determined as the main components in the essential oil obtained from the aerial parts of the species, the main components in the essential oil obtained from the roots were observed as borneol, myrtenol and α-campholenol.

DOI
http://doi.org/10.25135/rnp.459.2401.3008
Keywords
Essential oil extracts GC-MS headspace HPLC
Available online: May 30, 2024
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