Records of Natural Products
A scientific open access journal in the field of natural products.
Records of Natural ProductsA scientific open access journal in the field of natural products.
Trichonafurin A: a New γ-Lactone Compound from the Marine-Derived Fungus Trichoderma atroviride ZW-7
A new γ-lactone compound, trichonafurin A (1), was obtained from the culture of Trichoderma atroviride ZW-7, an endophyte of the marine brown alga Sargassum thunbergii. Its structure was unambiguously assigned by detailed interpretation of 1D/2D NMR and HRESIMS data. Trichonafurin A (1) exhibited moderate cytotoxicity against HeLa and HepG2 cell lines with IC50 values of 20.2 and 32.1 μM, respectively.DOI http://doi.org/10.25135/rnp.388.2302.2714 Keywords Trichoderma atroviride secondary metabolites cytotoxic activity Available online: March 22, 2023 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
A New Ingenane Diterpenoid from Euphorbia jolkinii
A new ingenane diterpenoid, named ingenol-20-laurate (1), and two known analogues (ingenol-20-palmitate (2), ingenol-20-pentadecanoate (3)) and an ent-abietane diterpenoid (euphopilolide, 4) were isolated from the whole plants of Euphorbia jolkinii. The structure of compound 1 was elucidated by HRESIMS and 2D NMR methods. The cytotoxicities of compound 1 against SMMC-7721, MDA-MB-231, and SW480 cell lines were 27.22±0.58, 17.69±0.29 and 16.19±0.77 μM, respectively.DOI http://doi.org/10.25135/rnp.384.2301.2685 Keywords Euphorbia jolkinii diterpenoids cytotoxicities Available online: March 22, 2023 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
A New Megastigmane Glycoside and Anti-Inflammatory Bibenzyls from the Stems of Dendrobium henanense
A new megastigmane glycoside, namely (9S)-O-β-D-glucopyranosyl-2,5-megastigmen-4-one (1), along with seven known bibenzyls (2-8) were isolated from the aerial stems of Dendrobium henanense. Their structures were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-, 2D-NMR and HR-MS. The anti-inflammatory activities of compounds 1-8 evaluated its anti-inflammatory activity by inhibiting the production of inflammatory cytokines such as NO, TNF-α and IL-6 in LPS-stimulated RAW264.7 macrophages. Compounds 3, 4, 6-8 exhibited moderated anti-inflammatory activity with IC50 values of below 100 µΜ.DOI http://doi.org/10.25135/rnp.382.2211.2626 Keywords Dendrobium henanense megastigmane glycoside anti-inflammatory RAW264.7 macrophages Available online: March 10, 2023 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
A Novel Phenanthrene and An Undescribed Alkaloid from the Roots of Stephania tetrandra
A novel phenanthrene compound, diphenanthrin (1), and an undescribed alkaloid compound, N-chloromethylstephenanthrine (2), together with two known compounds (3-4) were isolated from the EtOH extract of the roots of Stephania tetrandra. Their structures were elucidated by 1D and 2D NMR, mass spectroscopy and comparison of NMR data with those of known compounds. In anti-inflammatory assay, compounds 3 and 4 showed the inhibitory effects on NO production, with IC50 values of 41.51 ± 0.20 and 23.87 ± 2.12 μM.DOI http://doi.org/10.25135/rnp.381.2212.2663 Keywords Stephania tetrandra phenanthrene alkaloid anti-inflammatory Available online: March 04, 2023 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.