Records of Natural Products
A scientific open access journal in the field of natural products.LATEST ARTICLES
A New Highly Oxygenated Isocoumarin from the Fungus Penicillium sp.
Penicillium is a significant source of bioactive compounds, with the well-known antibiotics penicillin and griseofulvin derived from P. chrysogenum and P. griseofulvum, respectively. In our study, the fungus Penicillium sp. was isolated from shallow-sea sediments. The ethyl acetate extract of this strain exhibited moderate inhibitory effects against Escherichia coli. Subsequent isolation and purification of the extract led to the identification of five compounds (1-5), including a new highly oxygenated isocoumarin and two analogues (2 and 3), as well as two furan derivatives (4 and 5). The structure determination of compound 1 was conducted by extensive analysis of spectroscopic data, including 1H and 13C NMR, as well as 2D NMR techniques (HSQC, COSY, HMBC, and NOESY), in addition to HRESIMS. The known compounds 2-4 were identified as decarboxydihydrocitrinone (2), phenol A acid (3), 5-(hydroxymethyl)furfural (4), 5-hydroxymethyl-2-furancarboxaldehyde (5) by comparing their 1H and 13C NMR data with those reported in the literature. compound 1 exhibited an MIC value of 64 mg/mL toward Escherichia coli.
DOI http://doi.org/10.25135/rnp.481.24.08.3314 Keywords Penicillium sp. isocoumarin fungus isolation structure elucidation Available online: October 26, 2024 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.Phytochemistry, Pharmacology and Clinical Applications of Cortex Daphnes:A Review
Cortex Daphnes, a traditional Chinese medicine, has been utilized in China for millennia owing to it’s anti-inflammatory and analgesic properties. As it is belonging to the Thymelaeaceae family within the genus Daphne, it has traditionally been employed to dispel wind, eliminate dampness, alleviate pain, and dissipate blood stasis. Consequently, numerous scholars both domestically and internationally have investigated it’s chemical composition, pharmacological effects, and various other aspectsAmong these, daphnetin stands out as the primary active constituent in C. Daphnes, holding significant value as a precursor molecule for drug development. Pharmacological research has demonstrated that compounds and extracts derived from C. Daphnes exhibit notable activities, including anti-inflammatory, anti-tumor, antibacterial, immunomodulatory, antioxidant, and analgesic effects. Clinically, C. Daphnes has a long-standing history of use in the treatment of rheumatic diseases. This presents considerable potential for further development and exploration. According to existing records, C. Daphnes exhibits low toxicity; therefore, refining its processing technology, conducting toxicological studies, and establishing a comprehensive quality standard system are current challenges that need to be addressed. In this review, the botany, traditional uses, phytochemistry, pharmacology, and clinical applications of C. Daphnes, with the aim of providing a valuable reference for its future development and resource utilization was summarized.
DOI http://doi.org/10.25135/rnp.475.2405.3230 Keywords Cortex Daphnes botany phytochemistry pharmacology clinical applications adverse effects and toxicology Available online: September 15, 2024 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.