Records of Natural Products

A scientific open access journal in the field of natural products.
Editor-in-Chief: Gülaçtı Topçu
Co-Editor-in-Chief: Ahmet C Gören

LATEST ARTICLES

Short Report

A New Diterpenoid with Antitumor Cytotoxicity from Millipede

Rec. Nat. Prod. (2021) in press ; 1 - 5
by Zhimei Shang , Yike Fang , Zongyu Yang , Wanli Luo , Xiaofei Li and Shiji Xiao

 A new diterpenoid, namely millipedine A (10), along with nine known compounds (19), were isolated from the methanol extract of Millipede. Their structures were established on the basis of spectroscopic analysis including one and two-dimensional NMR spectroscopy and comparison with previously reported data. New compound showed moderate cytotoxicity against A549, HCT-116, and SW1990 cell lines in MTT assay.

DOI
http://doi.org/10.25135/rnp.278.21.07.2135
Keywords
Millipede diterpenoid antitumor activities
Available online: September 05, 2021
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Original Article

The Limonoids and Other Constituents from the Fruits of Melia azedarach and Their Biological Activity

Rec. Nat. Prod. (2021) in press ; 1 - 9
by Nguyen Ngoc Tuan , Ping-chung Kuo , Vu Dinh Hoang , Vu Thi Hien , Le Dang Quang , Tran Trung Hieu , Yue-chiun Li , Nguyen Tan Thanh , Tian-shung Wu and Tran Dinh Thang

Eleven chemical constituents, including one new limonoid trichilinin G (1), were identified from the fruit extracts of M. azedarach. The structure of 1 was established by various spectroscopic and mass spectrometric analyses. Among the eleven isolated compounds, trichilinin G (1) and meliatoxin B1 (2) were examined for their antifungal activity against Fusarium oxysporum, Magnaporthe grisea, Phytophthora spp. (PS), and P. capsici (PC). Limonoid 2 showed the best antifungal activity against PS (IC50 = 103.8 µg/mL) and PC (IC50 < 62.5 µg/mL) in a dose-dependent manner. While limonoid 1 exhibited a weak to moderate activity against these Phytophthora species, F. oxysporum and M. grisea were less sensitive to the two compounds tested. The inhibitory effects of trichilinin G on superoxide anion generation and elastase release by human neutrophils were also assessed in cellular model and did not show significant activity.

DOI
http://doi.org/10.25135/rnp.277.21.06.2097
Keywords
Triterpenoid limonoid trichilinin antifungal anti-inflammatory
Available online: September 05, 2021
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Original Article

A New Organic Acid Derivative from the Fruits of Rosa roxburghii

Rec. Nat. Prod. (2021) in press ; 1 - 4
by Xin Yin , Yongqiang Zhou , Shuang Zhang and Ying Zhou

Phytochemical investigation of the fruits of Rosa roxburghii resulted in the isolation of four organic acid derivatives and three phenylpropanoids, including a new organic acid derivative, Roxbuacidester A (1) and six known compounds (2-7). The structures of all isolates were established by 1D and 2D NMR spectra referring to the literatures, together with HR-MS spectrometric analysis. In addition, compounds 1 and 2 were evaluated for their inhibitory activities on nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in a RAW 264.7 cell line. Compounds 1 and 2 showed moderate inhibition of NO production with IC50 values of 46.8 ± 2.3 and 62.5 ± 3.7 μM, respectively.

DOI
http://doi.org/10.25135/rnp.276.21.07.2138
Keywords
Rosaceae Rosa roxburghii organic acid derivative
Available online: August 24, 2021
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Original Article

Anti-Obesity and Antihyperlipidemic Effects of Musa cavendishii

Rec. Nat. Prod. (2021) in press ; 1 - 13
by Mohammed S. Abdel-raziq , Fatma M. Abdel Bar , Sylvia A. Ashamallah , Nashwa Barakat and Ahmed Gohar

Obesity is a major risk factor in many health problems. This study explored the anti-obesity and antihyperlipidemic effects of Musa cavendishii Lamb. leaves. Doses of 1200 mg/kg of M. cavendishii methanol extract, or 300 mg/kg of fractions, were given to C57BL/6J mice fed with a high-fat diet (HFD) for 7 weeks. The reduction in fat volume was determined using CT scan and histopathological examination of mice livers. The results showed that the n-hexane and the EtOAc fractions reduced the body fat volume to 2.0% and 2.2% respectively, compared to 20.1% in the HFD group. Also, treated groups showed almost normal liver architecture with no fat vacuoles compared to the HFD group. Moreover, the treated groups showed a reduction in the levels of some obesity-related biochemical parameters, including plasma glucose, cholesterol, and triglycerides levels. Chromatographic fractionation of the bioactive n-hexane extract afforded four known compounds viz., palmitic acid (1), 5-methyl-5-(4,8,12-trimethyl-tridecyl)-dihydro-furan-2-one (2), cycloeucalenol (3), and stigmasterol (4). These compounds were in vitro and in silico studied for their pancreatic lipase (PL) inhibition. Compound 2 showed remarkable PL inhibition (89.8%) compared to orlistat (85.0%) at 200 µM, which was in full agreement with the docking scores (-7.19 and -4.05, respectively).

DOI
http://doi.org/10.25135/rnp.275.2103.2001
Keywords
musa cavendishii anti-obesity antihyperlipidemic banana leaf anti-adipogenesis pancreatic lipase
Available online: August 18, 2021
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