Records of Natural Products

A scientific open access journal in the field of natural products.
Editor-in-Chief: Gülaçtı Topçu
Co-Editor-in-Chief: Ahmet C Gören

LATEST ARTICLES

Original Article

Monoester-Type C19-Diterpenoid Alkaloids from Aconitum carmichaelii and Their Cardiotoxicity

Rec. Nat. Prod. (2021) in press ; 1 - 11
by Qiao Lin , Chunwang Meng , Jie Liu , Qinmei Zhou , Xingjie Ding , Lulin Miao , Xiaoya Wang , Ou Dai and Cheng Peng

A new (1) and six known (2-7) monoester-type C19-diterpenoid alkaloids were isolated from the lateral roots of Aconitum carmichaelii Debx. Their structures were determined by spectroscopic techniques and calculations of NMR chemical shifts. Compound 1 (1-epi-hokbusine A) was an aconitine-type diterpenoid alkaloid possessing an unusual 1β-methoxy group. According to the main toxicity of the lateral roots of A. carmichaelii, the cardiotoxic effects of the isolates were evaluated using H9c2 rat myocardial cells and zebrafish embryos. The results showed that all the monoester-type C19-diterpenoid alkaloids exhibited cardiotoxicity, and compound 6 was found to be the most toxic compound.

DOI
http://doi.org/10.25135/rnp.287.2107.2127
Keywords
Aconitum carmichaelii monoester-type C19-diterpenoid alkaloids H9c2 cells zebrafish embryos cardiotoxicity
Available online: October 25, 2021
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Original Article

Two New Seco-Abietanoids with Xanthine Oxidase Inhibitory Activity from Cryptomeria japonica D. Don

Rec. Nat. Prod. (2021) in press ; 1 - 8
by Chi-I Chang , Cheng-Chi Chen , Sheng-Yang Wang , Jih-Jung Chen , Chiy-Rong Chen , Che-Yi Chao and Yueh-Hsiung Kuo

Two new seco-abietanoids, 12-hydroxy-6-nor-5,6-secoabieta-8,11,13-trien-7-oic acid (1) and 7-hydroxy-7,8-secoabieta-8,12-diene-6,11,14-trione (3), together with one known seco-abietanoid, 12-hydroxy-6-nor-5-oxo-5,6-secoabieta-8,11,13-trien-7-al (2), were isolated from the methanol extract of the bark of Cryptomeria japonica. Their structures were elucidated by mean of spectroscopic analysis, as well as on  comparison of NMR data with those of known analogues. At a concentration of 50 μM, compounds 13 showed inhibitory activity toward xanthine oxidase by 38.2%, 55.9%, and 23.0%, respectively.

DOI
http://doi.org/10.25135/rnp.289.2106.2121
Keywords
Cupressaceae Cryptomeria japonica bark diterpenoid
Available online: October 25, 2021
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Short Report

A New Iridoid Glycoside Isolated from Valeriana officinalis L.

Rec. Nat. Prod. (2021) in press ; 1 - 5
by Guoqing Wu , Zilong Zhang , Hao Fan , Dongdong Zhang , Wenli Huang , Huawei Zhang , Yuze Li and Xiaomei Song

A new iridoid glycoside, (5S,7S,8S,9R)-7- hydroxy-∆4,11-dihyronepeta-1,3-diol-8-O-β-D-glucopyranosyl (1), along with 5 known compounds, dioscoridin A (2), jatamanin J (3), longiflorone (4), apigenin-8-O-β-D-glucopyranoside (5), isosakuranetin-5-O-rutinoside (6), were isolated from the Valeriana officinalis L. Their structures were determined by extensive analysis using various spectroscopic techniques. Moreover, the cytotoxic activity assay toward three human tumor cell (A549, HCT116 and SW620) lines were evaluated by the MTT method in vitro for compounds 1-2, using cisplatin as positive control. Experimental results showed that these compounds displayed weak cytotoxicity in the human cancer cell lines. Notably, compounds 2, 3 and 6 were firstly isolated from this plant, compound 4 was isolated from the genus Valeriana for the first time, compound 5 was isolated for the first time from Valerianaceae family.

DOI
http://doi.org/10.25135/rnp.283.2107-2145
Keywords
Iridoids Valeriana officinalis L. Valerianaceae cytotoxicity
Available online: October 25, 2021
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Original Article

Honeybee Propolis Phenol, Caffeic Acid Phenethyl Ester, Attenuates Cisplatin-Induced Kidney Damage – a Multitarget Approach

Rec. Nat. Prod. (2021) in press ; 1 - 14
by Branka Mitic , Dusan Mitic , Milica Radic , Milica Stankovic , Mihailo Sokolovic , Jelena Milovanovic , Nebojsa Arsic and Dusan Sokolovic

Cisplatin utilization is known to be limited due to numerous side effects, especially to the ones related to kidney tissue injury. The application of antioxidants, as potential supportive drugs, to prevent oxidative cisplatin tissue damage appears intuitive. In this work, we explored the usage of caffeic acid phenethyl ester (CAPE) in this respect through the analysis of standard serum biochemical parameters and the ones related to oxidative tissue damage, the changes in arginine metabolism, and apoptosis occurrence that follow cisplatin application in rat kidneys. Additionally, pathohistological analysis and a specific TUNEL staining for the detection of apoptosis was studied. Cisplatin produced marked changes in serum parameters that reflect kidney tissue function, while at the same time produced extensive tissue oxidative damage, increased arginase activity, and depleted reduced glutathione. Moreover, both biochemical and micromorphological analyses indicated significant tubular cell apoptosis. The application of CAPE together with cisplatin prevented the disturbance in serum biochemical and tissue oxidative stress parameters, without affecting arginase activity. Interestingly, CAPE inhibited different enzymes involved in the glutathione metabolism and the apoptotic process. The results of the present study indicate that CAPE could be used as supportive therapy for oncological patients receiving cisplatin since it attenuates the nephrotoxicity of this chemotherapeutic.

DOI
http://doi.org/10.25135/rnp.284.2107.2146
Keywords
Caffeic acid phenethyl ester kidney cisplatin oxidative damage arginase apoptosis
Available online: October 14, 2021
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