Records of Natural Products
A scientific open access journal in the field of natural products.LATEST ARTICLES
A New Acyclic Compound from the Medicinal Plant Tinospora sinensis

In this study, chemical investigation of the aerial parts of the medicinal plant Tinospora sinensis yielded five compounds (1-5), including a new acyclic compound (1) and four known compounds (2-5). Their structures were determined by extensive analysis of the spectroscopic data, including 1D (1H and 13C NMR) and 2D NMR data (HSQC, COSY, and HMBC). Compounds 3-5 were identified to be stearic acid (3), abscisic acid (4), and blumenol A (5) based on comparisons of the NMR data with those reported in the literature. The NMR data for 2-hydroxy methyl stearate (2) were reported for the first time in CDCl3 in this study. The compounds were evaluated for their antitumor potential against A549 cell line, while all were inactive (25 mM). Besides, compound 1 demonstrated marginal inhibition (19.35%) of LPS-induced NO production in RAW 264.7 cells (50 mM).
DOI http://doi.org/10.25135/rnp.530.2505.3536 Keywords Tinospora sinensis acyclic compound NMR Available online: July 26, 2025 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.Phytochemical Characterization, Antifungal Activity and Docking Investigation of The Isolated Compounds from Lippia callicarpifolia








Bioassay-guided fractionation of extracts of aerial parts from Lippia callicarpifolia usingvia chromatographic techniques led to the isolation of two D:C-friedours-7-ene compounds, namely D:C-3-oxo-friedours-7-en-28-oic acid (1) and a new callicarpifolic acid (2). Furthermore, additional known compounds, β-sitosterol glucoside (3) and genkwanin (4) were also identified. The structures of the natural products were established by 1D and 2D NMR, IR, and spectrometric analysisanalyses. In the antifungal assays, Fusarium sporotrichioides NRLL was sensitive to compounds 1 and 4 in the concentration range of 0.250-–1 mg/mL. The docking investigation revealed high inhibition of the trichodiene synthase enzyme by compound 4.
DOI http://doi.org/10.25135/rnp.535.2502.3432 Keywords Lippia callicarpifolia Fusarium sporotrichioides genkwanin callicarpifolic acid Available online: July 26, 2025 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.Isolation and Identification of Diterpenoids from Euphorbia helioscopia and Their Anti-inflammatory Activities

Phytochemical investigation of 70% ethanol extract of Euphorbia helioscopia led to eight diterpenoids, including four jatrophane-type (1–4), three abietane-type (5–7) and one lathyrane-type (8). Among them, (5E,11E)-3β-benzoyloxy-7β,14α,15β-trihydroxyjatropha-9-one (1) was a new jatrophane diterpenoid. An extensive array of spectral analyses, including HR-ESI-MS, IR, UV, 1D and 2D NMR, as well as quantum chemical calculations of ECD curve, were utilized for their structural elucidation. Bioassay results showed that compounds 2–3 and 6–8 could significantly inhibit NO release on LPS-induced RAW 264.7 cells, especially for jatrophane diterpenoid 3 and abietane diterpenoid 8 that showed stronger activities with the IC50 values of 9.16 ± 0.70 and 5.74 ± 0.27 μM.
DOI http://doi.org/10.25135/rnp.533.2502.3446 Keywords Euphorbia helioscopia diterpenoids anti-inflammatory Available online: July 26, 2025 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.A New Lignan with Potential Anti-inflammatory Activity from Notopterygium incisum

NNotopterygium incisum is widely used in clinical practice because of its complex chemical composition and remarkable pharmacological effects. In this study, a previously undescribed lignan (1) was isolated from N. incisum. Its structure was evaluated through examinations of the NMR, HREIMS data and ECD calculation. Compound 1 demonstrated significant anti-inflammatory potential by inhibiting the secretion of nitric oxide (NO) in lipopolysaccharide (LPS)-induced macrophages, with an IC50 value of 3.57 μM.
DOI http://doi.org/10.25135/rnp.2505.3518 Keywords Notopterygium incisum lignan anti-inflammatory activity Available online: July 14, 2025 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.