Organic Communications
A scientific open access journal in the field of synthetic organic chemistry and polymers
Editor-in-Chief:
Hasan Seçen
Review Article and Book Review Editor:
Turan Ozturk
Synthetic Polymer Section Editor:
Mehmet S. Eroglu
Co-Editor-in-Chief:
Ahmet C Goren
LATEST ARTICLES
Original Article
Baker’s yeast as a biocatalyst for efficient and substrate-selective N-acetylation of anilines
Org. Commun. (2025) in press ; 1 - 11
by
Qasim Ullah 
,
Samreen Kausar
,
Abida Murtaza
and
Aarifa Maryam
,
Samreen Kausar
,
Abida Murtaza
and
Aarifa Maryam
In the present study, we have developed an efficient N-acetylation method of anilines under green and eco-friendly conditions, where Baker’s Yeast (BY) was used as biocatalyst. The results of this study clearly demonstrate towards the N-acetylation of only anilines to form acetanilides (3a-i) with acetic anhydride in good to excellent yield. Interestingly, acetylation of phenol/thiophenol, aliphatic amines/heterocyclic amines and amino acids failed under the same conditions. This N-acetylation reaction with substrate-selective follows simple procedure and requires simple work up. Thus, we can conclude that the present method is a simple, efficient, substrate selective and eco-friendly.
DOI http://doi.org/10.25135/acg.oc.182.2501.3412 Keywords Anilines acetylation acetanilide ethanoic anhydride Baker yeast bio-catalyst Available online: March 22, 2025 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.