Organic Communications

Abstract: This concise review provides an overview of some synthetic methods utilized for the preparation of 4(3H)-quinazolinone and benzotriazepine derivatives, and explores their diverse biological activities. The review highlights the significance of these compounds in medicinal chemistry and discusses selected synthetic approaches employed in their synthesis. Additionally, it examines the range of biological activities exhibited by these derivatives and briefly discusses their potential applications. This succinct review serves as a valuable resource for researchers interested in the synthesis and biological evaluation of 4(3H)-quinazolinone and benzotriazepine derivatives.

A facile and useful method for synthesis of 1-benzylidene semicarbazones was introduced in this work. The reaction of synthesis of the corresponding 1-benzylidene semicarbazone derivatives is carried out in the presence of acetonitrile-UHP/NH4OAc. In this method, NH4OAc was used as a source of ammonia and urea-hydrogen peroxide (UHP) as reagent. The key advantages of this process are elimination of semicarbazide, good yields and cheap reagents. All products were characterized by common techniques (infrared, 1H NMR, and melting point).