A scientific open access journal in the field of synthetic organic chemistry and polymers
Organic CommunicationsA scientific open access journal in the field of synthetic organic chemistry and polymers
Ultrasound-assisted efficient synthesis of 3-[4-(2-methoxyethyl) phenoxy] propane -1,2 -diol (Metoprolol EP impurity D)
Safety of the drug molecule is dependent on the various impurities formed during chemical transformation which may cause drug product instability, decreased product performance, loss in potency, and/or formation of potentially genotoxic impurities. Therefore, it is essential to identify and quantify the impurities generated during the drug development stage. Herein, we describe the synthesis and characterization of Impurity D of Metoprolol, 3-[4-(2-methoxyethyl)phenoxy]propane-1,2-diol (1), reported in European Pharmacopeia. The synthesis of impurity D has been accomplished in two steps; starting from Epichlorhydrin under three different set of conditions.DOI http://doi.org/10.25135/acg.oc.184.108.40.2064 Keywords Keywords: Impurity D Metoprolol synthesis characterization ultrasonic waves DETAILS PDF OF ARTICLE © 2021 ACG Publications. All rights reserved.
Knoevenagel condensation reaction catalysed by agro-waste extract as a greener solvent catalyst
This paper present a novel Knoevenagel reaction protocol for the condensation of aromatic/heteroaromatic aldehydes with malononitrile to give α, β–unsaturated benzylidene derivatives. The main focus of this work is to reveal the usability of agro-waste extracts as a catalyst in the Knoevenagel condensation. The present protocol proceeds efficiently for various substituted aromatic and heterocyclic aldehydes in the Knoevenagel reactions. In addition, the present method describes direct isolation of the formed products without using organic solvent extraction gave good yields product.DOI http://doi.org/10.25135/acg.oc.99.21.01.1948 Keywords green chemistry Agro-waste Knoevenagel condensation solvent-free DETAILS PDF OF ARTICLE © 2021 ACG Publications. All rights reserved.
Swelling and durability performance of surface-grafted polymer brushes and brush gels
Polymer brushes and brush gels were prepared by RAFT polymerization. Prepared surfaces were characterized by XPS, AFM, ellipsometry, and water contact angle measurements. The swelling properties and stability of surfaces were compared. It was determined that the swelling ratio decreased with increasing grafting density and cross-linker ratio for polymer brushes and brush gels, respectively. As a result, it was observed that cross-linked polymer brushes were more stable than polymer brushes, and the stability and swelling properties of polymer brushes could be controlled by cross-linking.
DOI http://doi.org/10.25135/acg.oc.96.2012.1902 Keywords Polymer brush brush gels polymeric ionic liquid RAFT polymerization DETAILS PDF OF ARTICLE © 2021 ACG Publications. All rights reserved.
Exploring the in-silico approach for assessing the potential of natural compounds as a SARS-CoV-2 main protease inhibitors
The SARS-CoV-2 virus emerged as a major cause of the COVID-19 pandemic in December 2019. Many attempts have been made to block the viral infection by targeting various processes like its entry, uncoating, replication, activating T cells response, and rising antibody titer. Also, many drugs are repurposed like remdesivir, dexamethasone, tocilizumab, hydroxychloroquine based on their established therapeutic efficacy against other viruses in the past. Natural products (NP) consist of a promising candidate and are needed to evaluate those molecules with molecular docking for preliminary screening and in vitro studies. Therefore, in the present study, a total of 12 active constituents from natural products like Ashwagandha, Tinospora cordifolia, Tea, Neem and lemon balm were docked, using the Autodock tool, onto the crystal structure of SARS CoV-2 main protease (PDB ID-5R80), to study their capability to act as main protease (Mpro) COVID-19 inhibitors. All NPs derivatives displayed good binding energies (ΔG) ranging from -8.8 to -5.2 kcal/mol, but berberine, epicatechin, and rosmarinic acid were found most potent, among others. Therefore, good binding energy, drug-likeness, and efficient pharmacokinetics suggest the potential of NPs derivatives as SARS-CoV-2 main protease (Mpro) inhibitors. However, further research is necessary to investigate the ability of these compounds as COVID-19 inhibitors.DOI http://doi.org/10.25135/acg.oc.97.2012.1895 Keywords SARS-CoV-2 main protease natural products molecular docking viral infection drug-likeness DETAILS PDF OF ARTICLE © 2021 ACG Publications. All rights reserved.