Organic Communications

Articles In Press

Original Article

1) Waste to wealth: Agro-waste catalyzed green method synthesis of 5-aryl-1,2,4-triazolidine-3-thiones and 1,2,4-triazospiro-3-thiones

Org. Commun. (2021) in press ; 1 - 15
by Santosh Y. Khatavi and Kantharaju Kamanna

TThis paper describes novel agro-waste derived Water Extract of Orange Fruit Shell Ash (WEOFSA) catalyzed synthesis of 5-aryl-1,2,4-triazolidine-3-thiones and 1,2,4-triazospiro-3-thiones under microwave irradiation. Herein, we have developed inexpensive, facile and green method synthesis of cyclic thiones by the reaction of aromatic aldehyde and cyclic ketone, with thiosemicarbazide in presence of agro-waste derived catalyst. The obtained product is chromatographically pure after recrystallization from ethanol, and final product is characterized by various spectroscopic techniques FT-IR, 1H-, 13C-NMR and HR-MS.

DOI
http://doi.org/10.25135/acg.oc.107.21.04.2040
Keywords
Agro-waste green method cyclic ketone semicarbazide microwave
Available online: July 21, 2021
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Short Communication

2) Friedel−Crafts benzylation of arenes with benzylic alcohols using sulfonic-acid-functionalized hyper-cross-linked poly(2-naphthol) as a solid acid catalyst

Org. Commun. (2021) in press ; 1 - 5
by Reddi Mohan Naidu Kalla , Raju Chakali , Munikrishna Amudala , Mavallur Varalakshmi and Chamarthi Nagaraju

The porous poly(2-naphthol) was made-up by combining the 2-naphthol, dimethoxymethane as an cross linker in presence of FeCl3. Furthermore the polymer was functionalized with ClSO3H to get a dense acid catalyst. The reagent is active for benzylation of arenes with benzylic alcohols irrespective of the nature of substituted arenes. This catalyst is good active compared with other acid catalyst used for Friedel−Crafts benzylation.

DOI
http://doi.org/10.25135/acg.oc.106.2104.2034
Keywords
Heterogeneous acid catalysis Friedel-Craft benzylation green chemical method recyclability
Available online: July 19, 2021
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Review Article

3) Synthesis of biologically active chromene, coumarin, azole, azine and thiophene derivatives from 1,3-diketone

Org. Commun. (2021) in press ; 1 - 65
by Ensaf Alwan and Rafat Mohareb

IIn the present review, we discuss new and diverse methods for synthesizing chromene, coumarin, pyrimidine, pyridine, pyrazole, thiazole and thiophene derivatives from 1,3-diketones, according to Knoevenagel condensation, Michael addition, Hantzsch reaction, and Gewald’s reaction. Various catalysts and reagents were used to complete the cyclization processes. Most of the produced compounds showed remarkable activity against different types of cancer cell lines and toward Gram-negative and Gram-positive bacteria. Furthermore, anti-quorum sensing, in vitro COX-1 and COX-2 enzymatic inhibition assays were evalua

DOI
http://doi.org/10.25135/acg.oc.105.21.03.2027
Keywords
1,3-Diketone chromene pyridine thiophene anti-tumors
Available online: July 17, 2021
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