Organic Communications Articles
Articles In Press
Articles In Press
1) Waste to wealth: Agro-waste catalyzed green method synthesis of 5-aryl-1,2,4-triazolidine-3-thiones and 1,2,4-triazospiro-3-thiones
TThis paper describes novel agro-waste derived Water Extract of Orange Fruit Shell Ash (WEOFSA) catalyzed synthesis of 5-aryl-1,2,4-triazolidine-3-thiones and 1,2,4-triazospiro-3-thiones under microwave irradiation. Herein, we have developed inexpensive, facile and green method synthesis of cyclic thiones by the reaction of aromatic aldehyde and cyclic ketone, with thiosemicarbazide in presence of agro-waste derived catalyst. The obtained product is chromatographically pure after recrystallization from ethanol, and final product is characterized by various spectroscopic techniques FT-IR, 1H-, 13C-NMR and HR-MS.DOI http://doi.org/10.25135/acg.oc.107.21.04.2040 Keywords Agro-waste green method cyclic ketone semicarbazide microwave Available online: July 21, 2021 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
2) Friedel−Crafts benzylation of arenes with benzylic alcohols using sulfonic-acid-functionalized hyper-cross-linked poly(2-naphthol) as a solid acid catalyst
The porous poly(2-naphthol) was made-up by combining the 2-naphthol, dimethoxymethane as an cross linker in presence of FeCl3. Furthermore the polymer was functionalized with ClSO3H to get a dense acid catalyst. The reagent is active for benzylation of arenes with benzylic alcohols irrespective of the nature of substituted arenes. This catalyst is good active compared with other acid catalyst used for Friedel−Crafts benzylation.DOI http://doi.org/10.25135/acg.oc.106.2104.2034 Keywords Heterogeneous acid catalysis Friedel-Craft benzylation green chemical method recyclability Available online: July 19, 2021 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
3) Synthesis of biologically active chromene, coumarin, azole, azine and thiophene derivatives from 1,3-diketone
IIn the present review, we discuss new and diverse methods for synthesizing chromene, coumarin, pyrimidine, pyridine, pyrazole, thiazole and thiophene derivatives from 1,3-diketones, according to Knoevenagel condensation, Michael addition, Hantzsch reaction, and Gewald’s reaction. Various catalysts and reagents were used to complete the cyclization processes. Most of the produced compounds showed remarkable activity against different types of cancer cell lines and toward Gram-negative and Gram-positive bacteria. Furthermore, anti-quorum sensing, in vitro COX-1 and COX-2 enzymatic inhibition assays were evaluaDOI http://doi.org/10.25135/acg.oc.105.21.03.2027 Keywords 1,3-Diketone chromene pyridine thiophene anti-tumors Available online: July 17, 2021 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.