Records of Natural Products

Articles In Press

Short Report

1) Todasinoid A, a New Eremophilane-type Sesquiterpene from the Plant Toddalia asiatica

Rec. Nat. Prod. (2022) in press ; 1 - 6
by Lijing Cai , Mengying Zhang , Jie He and Tingting Lin

A new sesquiterpene, named todasinoid A (1), together with eight known compounds (2-9) were isolated from the roots of Toddalia asiatica. The gross structure of todasinoid A were established by analyses of the NMR and HRESIMS data. A comparison of the experimental ECD spectrum of 1 with the calculated ECD spectra for a model compound (1a) resolved the absolute configuration of 1. The known compounds were identified to be bullatantriol (2), aculeatin (3), 6-(3-ethoxy-2-hydroxy-3-methylbutyl)-5,7-dimethoxy-2H-1-benzopyran-2-one (4), trans-N-p-coumaroyltyramine (5), feruloyltyramine (6), b-sitosterol (7), sitosterol D-glucoside(8), 7α-hydroxysitosterol (9) by comparing the NMR data and specific rotations with reported data in literature. Compound 1 is an eremophilane-type sesquiterpenoid containing a mercaptolactate side-chain that is rarely found in nature. Compounds 2, 5, and 9 were isolated from this plant for the first time. Bioassay study revealed that compound 5 exhibited inhibitory effects against a-glucosidase with an IC50 of 320 mM, being more active than the positive control acarbose.

DOI
http://doi.org/10.25135/rnp.356.2206.2486
Keywords
Toddalia asiatica Todasinoid A sesquiterpenoid ECD calculation
Available online: September 22, 2022
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Short Report

2) Plagranline A, a Novel β-carboline and the First Alkaloid Isolated from Platycodon grandiflorus

Rec. Nat. Prod. (2022) in press ; 1 - 5
by Ju-Tao Wang , Lan Ding , Ren-nai Yang , Liang-ping Zha , Yang Yu and Shuang-ying Gui

 A novel β-carboline, namely Plagranline A (1), and a known alkaloid (2) were isolated from the roots of Platycodon grandiflorus. Their structure was elucidated using a combination of spectroscopic analyses and computational chemistry, including electronic circular dichroism (ECD) and optical rotatory dispersion (ORD). Alkaloids 1 and 2 exhibited moderate inhibitory effects against NO production. Interestingly, 1 and 2 are the first alkaloid constituents reported from the plant P. grandifloras.

DOI
http://doi.org/10.25135/rnp.354.2207.2510
Keywords
Platycodon grandiflorus β-carboline computational chemistry alkaloid anti-inflammatory activity
Available online: August 26, 2022
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Original Article

3) A New Monoterpene Alkaloid From the Stems of Rauvolfia vomitoria

Rec. Nat. Prod. (2022) in press ; 1 - 9
by Kailing Yang , Tao Yang , Xiaolei Li , Ruixi Zhou , Rongkun Miao , Yuyan Guan , Yang Teng , Guanqun Zhan and Zengjun Guo

One new monoterpene alkaloid (1) and eight known compounds (29), belonging to two monoterpene alkaloids (12), one pyridine alkaloid (3), four phenylpropanoid derivatives (47), and two matrine-type alkaloids (89), were isolated from Rauvolfia vomitoria Afzel. The structure of new compound 1 was determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation. Notably, this is the first reported monoterpene alkaloids from R. vomitoria. Besides, compounds 3, 5, and 79 were first discovered in the Apocynaceae family and compounds 4 and 6 were first reported in the Rauvolfia genus. This is also the first example of matrine-type alkaloids reported in the Apocynaceae family, indicating that matrine-type alkaloids are not unique to the Leguminosae/Fabaceae family. All isolated compounds were evaluated for their anti-acetylcholinesterase, anti-α-glucosidase, and antioxidant activities. Compound 6 showed significant α-glucosidase inhibitory activity and remarkable DPPH radical scavenging capacity, both of which are superior to the positive controls. Molecular docking of compound 6 with α-glucosidase was further performed, suggesting that compound 6 could form hydrogen bonds with residues ALA-292, ASN-259, and ARG-263.

DOI
http://doi.org/10.25135/rnp.353.2204.2432
Keywords
Rauvolfia vomitoria AChE DPPH α-glucosidase monoterpene alkaloids molecular docking
Available online: August 26, 2022
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Review Article

4) Genus Lactuca (Asteraceae): A Comprehensive Review

Rec. Nat. Prod. (2022) in press ; 1 - 32
by Fatma M. Abdel Bar , Nouran H. Abdel Fatah , Yhiya Amen , Ahmed F. Halim and Hassan-Elrady A. Saad

Genus Lactuca L. belongs to one of the major families of flowering plants, Asteraceae. It includes about 150 species, distributed in warm and temperate areas, commonly in the Northern Hemisphere. Since ancient times, numerous Lactuca L. species have been cultivated for their economic and medicinal significance. Cultivated lettuce (Lactuca sativa), a representative member of the genus, is the most important leafy salad vegetable. The current review aims to provide comprehensive information on the taxonomy, phytochemistry, traditional uses, and biological activities of plants of the genus Lactuca.

DOI
http://doi.org/10.25135/rnp.350.2205-2474
Keywords
Lactuca Asteraceae Lettuce Phytochemistry Sesquiterpene lactones Biological activities
Available online: August 21, 2022
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Short Report

5) Cytotoxic Constituents from the Rhizomes of Monstera deliciosa

Rec. Nat. Prod. (2022) in press ; 1 - 5
by Marwa Elsbaey , Kadria F. Ahmad , Fathy Behery , Mohamed Amer and Mohamed Farid Lahloub

A phytochemical study of the rhizomes of Monstera deliciosa has led to isolation of fourteen compounds (1-14) for the first time from the plant species. The structure elucidation was carried out using 1D and 2D NMR data. The cytotoxic activities of the compounds against the liver (HepG-2), larynx (Hep-2), colon (HCT-116), and breast (MCF-7) cancer cell lines were evaluated using MTT assays. Syringaresinol (6) showed remarkable IC50 values against the four tested cell lines. In addition, 9, 12, 13-trihydroxy-10-octadecenoic acid (14) was highly cytotoxic against Hep-2 and HCT-116 cell lines.

DOI
http://doi.org/10.25135/rnp.352.2203.2390
Keywords
Monstera Araceae cytotoxic lignan
Available online: August 20, 2022
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Short Report

6) TTrichocarotin N: a New Carotane Sesquiterpene from the Marine-Derived Fungus Trichoderma virens QD-11

Rec. Nat. Prod. (2022) in press ; 1 - 4
by Wen-Ting Yang , Wei Gao , Jin-An Liu , Xiao-Xiao Liu and Lin-chuan Jia

A new carotane sesquiterpene, trichocarotin N (1), was isolated from the culture of marine-derived fungus Trichoderma virens QD-11. Its structure was established by detailed analysis of 1D/2D NMR and HRESIMS data. Trichocarotin N (1) exhibited moderate cytotoxicity against HeLa and MCF-7 cancer cell lines, with IC50 values of 32.4 and 41.6 μM, respectively.

DOI
http://doi.org/10.25135/rnp.349.2206.2492
Keywords
richoderma virens carotane sesquiterpeneT secondary metabolites cytotoxic activity
Available online: August 14, 2022
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Original Article

7) Chemical Constituents of Tectus maximus Koch, 1844

Rec. Nat. Prod. (2022) in press ; 1 - 7
by Nguyen Trong Dan , Le Thi Giang , Nguyen Dinh Cu , Truong Ba Hai , Nguyen Dang Hoi , Vu Thi Loan , Dan Thi Thuy Hang , Nguyen Xuan Nhiem , Tai Bui Huu and Kiem Van Phan

Two previously unreported compounds (1 and 2) together with eight known compounds (3-10) were isolated from the methanol extract of sea snail Tectus maximus Koch, 1844. Their chemical structures were determined to be 6-acetoxy-deoxyinosine (1), 6-acetoxy-inosine (2), deoxyinosine (3), inosine (4), adenosine (5), deoxyadenosine (6), deoxyuridine (7), thymidine (8), glycerol arachidonate (9), and arachidonic  acid (10) on the basis of HR-ESI-MS and NMR spectroscopic analyses. This is the first report of those compounds from the genus Tectus

DOI
http://doi.org/10.25135/rnp.351.2205.2462
Keywords
Tegulidae Tectus maximus 6-acetoxy-deoxyinosine 6-acetoxy-inosine
Available online: August 14, 2022
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Original Article

8) AAntidepressant-Like Effect of Aromatherapy with Magnolia sieboldii Essential Oils on Depression Mice

Rec. Nat. Prod. (2022) in press ; 1 - 15
by Yan Ai , Lin Geng , Xian Xu , Xiaolu Chen , Baoshan Rong , Zhiting Zhang , Lu Ren , Ni Song , Minghui Tang , Lanyue Zhang , Yong Ai and Tinggang He

 Globally, depression is the fourth most common disorder. It is difficult to treat and prone to recurrent episodes. To elucidate the antidepressant effect and mechanism of action of Magnolia sieboldii aromatherapy, the main components of M. sieboldii essential oils were analyzed using GC-MS. A mouse model of depression, established by repeated intraperitoneal injection of reserpine, was used to probe antidepressant efficacy. Behavioral tests were used to evaluate depressive behavior in mice. In in vivo animal studies, changes in the number of measured neurons were detected using Nissl staining, and GR protein expression was examined using immunohistochemistry. The relative expression levels of 5-hydroxytryptamine (5-HT1A) and brain-derived neurotrophic factor (BDNF) were detected using western blot (WB). The results showed that the essential oils of M. sieboldii are mainly composed of β-elemene (22.11%), trans-β-ocimene (14.87%), germacrene D (7.27%), and nerolidol (4.51%). The expression of GR protein was substantially upregulated in the tissues of mice treated with the essential oils of M. sieboldii. WB showed that the components of M. sieboldii essential oils modulated the expression of BDNF and 5-HT in serum, which remarkably attenuated depressive behavior in mice. In addition, a medium concentration of M. sieboldii substantially ameliorated depressive-like behavior in mice and increased the serum levels of 5-HT1A and BDNF. This study suggests that a medium concentration of M. sieboldii has a prominent antidepressant effect.

DOI
http://doi.org/10.25135/rnp.341.2204.2434
Keywords
Magnolia sieboldii essential oils depression BDNF 5-HT
Available online: August 14, 2022
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Original Article

9) Chemical Constituents from the Whole Plant of Pachysandra terminalis

Rec. Nat. Prod. (2022) in press ; 1 - 9
by Chao Ding , Yuze Li , Ying Wu , Yu Sun , Fengrui Wang , Huawei Zhang , Yi Jiang , Dongdong Zhang and Xiaomei Song

Two new compounds, butyl(Z)-3-((3R,4R)-5-(hydroxymethyl)-3,4-dimethyl-3,4-dihydro- 2H-pyran-6-yl)acrylate (1) and (2Z,4S)-4,5-dihydroxy-3,4-dimethylpent-2-enoic acid (2) along with seven known ones, stigmast-5,28(29)-dien-3β-ol (3), β-sitosterol (4), carotene (5), fraxetin (6), p-coumaric acid (7), cis-p-hydroxycinnamic acid (8), ferulic acid (9) were obtained from the whole plant of Pachysandra terminalis. The structures of these compounds were elucidated by comprehensive spectroscopic methods including 1D, 2D NMR, MS, IR and ECD data analysis. Notably, compounds 3 and 5~8 were isolated from genus Pachysandra for the first time. Moreover, compounds 1~3 and 6~8 were tested their cytotoxic activities against three cancer cells, however, only compound 1 showed inhibitory effect in SW620 cells with IC50 value of 47.7 μM.

DOI
http://doi.org/10.25135/rnp.346.2205.2465
Keywords
Pachysandra terminalis chemical composition isolation and purification steroids fatty acids
Available online: August 06, 2022
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Short Report

10) Polyketides and Alkaloids from the Deep-Sea-Derived Fungus Aspergillus fumigatus CBC18132

Rec. Nat. Prod. (2022) in press ; 1 - 6
by Yu Liu , Fan Yang , Xiaoqian Zhang , Ying Qiao , Wei Xu , Qin Li and Zhongbin Cheng

Abstract: The fungal strain Aspergillus fumigatus CBC18132, isolated from deep-sea sediment, was investigated for secondary metabolites. Fermentation on rice medium followed by chromatographic separation led to the isolation of three polyketides (13) and nine alkaloids (413). The structures were determined by analyses of spectroscopic data (1H and 13C NMR, and MS data). The absolute configuration of the anthraquinone-derivative trypacidin was resolved for the first time by a combination of ECD and specific rotation calculation. All isolated compounds were inactive toward the -glucosidase at the initial concentration of 2 mM.

DOI
http://doi.org/10.25135/rnp.348.2204.2447
Keywords
Aspergillus fumigatus trypacidin absolute configuration
Available online: August 06, 2022
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Original Article

11) Tigliane-Type Diterpenoids from the Seeds of Croton tiglium

Rec. Nat. Prod. (2022) in press ; 1 - 6
by Lijuan Zhang , Fei Li , Jianyong Zhu and Qian Niu

A new tigliane-type diterpenoid (1) and three known analogues (2-4) were isolated from the seeds of Croton tiglium. Extensive spectroscopic analyses, especially the 2D NMR experiments were used to determine their structures. The absolute configuration of 1 was defined by single-crystal X-ray diffraction data. The cytotoxicity 1-4 was evaluated against melanoma cell line A375, and the results showed that compounds 1, 3, and 4 exhibited certain cytotoxicities.

DOI
http://doi.org/10.25135/rnp.344.2205.2455
Keywords
Croton tiglium tigliane-type diterpenoid cytotoxicity
Available online: July 29, 2022
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Original Article

12) The First Example of Di--Methane Rearrangement in Nature: Cephalotanols A and B, Two Novel Rearranged Norlignan Glycosides from Cephalotaxus fortunei Hook

Rec. Nat. Prod. (2022) in press ; 1 - 9
by Xiaoyan Xie , Qingqing Zhou , Yanting Zhou and Jinbiao Xu

A pair of unique diastereoisomers of norlignan glycosides named cephalotanols A (1) and B (2), together with two known compounds, have been isolated from the twigs and leaves of Cephalotaxus fortunei Hook. Their structures were elucidated by using a combination of spectroscopic techniques and comparison of experimental and calculated electronic circular dichroism (ECD) data. To our knowledge, cephalotanols A and B represent the first rearranged norlignan glycosides with diphenylvinylcyclopropane core found in natural sources, of which biosynthetic pathways originating from co-occurring precursors 3S-4'-O-β-D-glucopyranosylhinokiresinol (3) and 3S-4''-O-β-D-glucopyranosylhinokiresinol (4) via di-π-methane rearrangement is proposed.

DOI
http://doi.org/10.25135/rnp.345.2205.2461
Keywords
Cephalotaxus fortune norlignan diphenylvinylcyclopropane structural elucidation di-π-methane rearrangement
Available online: July 28, 2022
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Original Article

13) Sesquiterpenes from theLeaves of Dalbergia odorifera

Rec. Nat. Prod. (2022) in press ; 1 - 10
by Chenxiao Shen , Can Yue Ouyang , Ying Zhang , Qing Zhu , Ronghua Liu and Lanying Chen

Two new sesquiterpenes (1R,5R,6R)-11-hydroxyl-drocostuslactone (1) and (1R,10S)- gibberodione A (2) were acquired from the leaves of Dalbergia odorifera. The structures of two new sesquiterpenes were revealed by broad NMR exploration, and X-ray crystallography analyses. In addition, the bioactivity assay showed that two compounds had potential anti-inflammatory activity with less toxicity (their IC50 values were 107.2 ± 4.02 and 54.64 ± 1.89 μg/mL), could significantly decrease the production of NO (P<0.01) with 8~16 and 1~2 μg/mL and inhibited LDH (P<0.01) with 1~16 and 1~2 μg/mL in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, respectively.

 

DOI
http://doi.org/10.25135/rnp.347.2205.2466
Keywords
Dalbergia odorifera sesquiterpenoids anti-inflammatory activity
Available online: July 28, 2022
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Original Article

14) Two New Disaccharide Glycosides from the Root Cortex of Paeonia ostii

Rec. Nat. Prod. (2022) in press ; 1 - 6
by Lei Sun , Huan Zhao , Chuihao Kong , Deling Wu and Fengqing Xu

Two new glycosides 2-hydroxy-4-methoxy-acetophenone-3-O-[β-D-apiofuranosyl (1→6)-β-D-glucoside (1) and 4-hydroxy-2-O-β-rutinosyl acetophenone (2), along with two known compounds, paeonolide (3), involcranoside B (4) were isolated from the roots of Paeonia ostii. In addition, compound 4 was isolated from this genus for the first time. Their structures were established on the basis of spectral and chemical evidence. All the compounds showed inactive nitric oxide (NO) inhibitory effects.

DOI
http://doi.org/10.25135/rnp.342.2206.2475
Keywords
Paeonia ostii disaccharide glycosides water-soluble extraction anti-inflammatory
Available online: July 25, 2022
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Short Communication

15) Myrrhalindenane C, a New Eudesmane Sesquiterpenoid From Lindera Myrrha Roots

Rec. Nat. Prod. (2022) in press ; 1 - 6
by Hoang-Dung Nguyen , Huy Truong Nguyen , Thi-Hoai-Thu Nguyen , Jirapast Sichaem , Huu-Hung Nguyen , Ngoc-Hong Nguyen and Thuc-Huy Duong

Phytochemical investigation of Lindera myrrha roots growing in Vietnam afforded a new eudesmane sesquiterpenoid, myrrhalindenane C (1), along with seven known compounds, rel-5-(3S,8S-dihydroxy-1R,5S-dimethyl-7-oxa-6-oxobicyclo[3,2,1]-oct-8-yl)-3-methyl-2Z,4E-pentadienoic acid (2), 1-O-(4-hydroxy-2,6-dimethoxyphenoxy)-6-O-[rel-5-(3S,8S-dihydroxy-1R,5S-dimethyl-7-oxa-6-oxobicyclo[3,2,1]-oct-8-yl)-3-methyl-2Z,4E-pentadienoyl]-β-D-glucopyranose (3), curcumin (4), demethoxycurcumin (5), bisdemethoxycurcumin (6), (1E,6E)-1,7-bis(4-methoxyphenyl)-1,6-heptadiene-3,5-dione (7), and 2',4',4,2''-tetrahydroxy-3'-[3''-methylbut-3''-enyl]chalcone (8). The structure was determined by analysis of their MS and NMR data as well as by comparison with literature values. All compounds were evaluated for antimicrobial activity against antibiotic-resistant, pathogenic bacteria Enterococcus faecium, Staphylococcus aureus, and Acinetobacter baumannii.

DOI
http://doi.org/10.25135/rnp.343.2203.2396
Keywords
Lauraceae Lindera myrrha myrrhalindenane C eudesmane antimicrobial activity
Available online: July 25, 2022
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Short Report

16) Lactones from Glomerella cingulata Cultivated in Rice:Structural Studies and Antimicrobial Evaluation

Rec. Nat. Prod. (2022) in press ; 1 - 6
by Nayara F. Gomes , Manoel Leão L. Júnior , Antônio José C. Filho , Lourivaldo S. Santos , Luís Cláudio N. Silva and Edson Rodrigues-Filho

Extracts of the endophytic fungus Glomerella cingulata grown in polish rice, were fractionated by chromatographic procedures including preparative scale HPLC. The isolated compounds were structurally elucidated through spectroscopic analysis, mainly 1H and 13C NMR and HRMS. These analyzes allowed the identification of pestalotin-1 (1) and the phthalides (3R*,8S*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide (2) and (3R*,8R*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide (3). The extracts, their fractions and isolated substances were tested against several bacteria. The lactone 2 showed some activity against lineages of E. coli and Enterococcus faecalis while its diastereoisomer 3 and pestalotin-1 were inactive.

DOI
http://doi.org/10.25135/rnp.340.2202.2352
Keywords
Endophytic fungus Glomerella cingulata antimicrobial activity
Available online: July 17, 2022
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Original Article

17) Novel Acyclic Diterpene from Bornean Local Red Chilli Pepper Capsicum frutescens L.

Rec. Nat. Prod. (2022) in press ; 1 - 6
by Kazuki Tani , Norhidayah Tumiran , Rolinus Paulous and Charles S. Vairappan

An unknown acyclic diterpene (3S, 6E, 10E, 14Z)-3-hydroxy-3,7,11,15-tetramethyl-1,6,10,14-hexadecatetraene acid (1) along with four known secondary metabolites (3S, 6E, 10E, 14Z)-20-hydroxygeranyllinalool (2), trans-capsaicin (3), nordihydrocapsaicin (4) and capsidiol (5) were isolated from the Bornean red chilli pepper Capsicum frutescens L. The structures of the secondary metabolites were determined based on spectroscopic data analysis such as NMR, HRESIMS, and IR data. The new compound 1 is a carboxylic acid precursor that would condensate with vanillylamine in the phenylpropanoid pathway in the biosynthesis of capsaicinoids. Discovery of this compound is an important milestone in our understanding of the capsaicinoids biosynthesis.

DOI
http://doi.org/10.25135/rnp.339.2204.2443
Keywords
Red Chilli Capsicum frutescens L. Bornean acyclic diterpene
Available online: July 14, 2022
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Short Report

18) A New Lignan from Leaves of Ormosia xylocarpa

Rec. Nat. Prod. (2022) in press ; 1 - 6
by Wenjuan Zhou , Yingxuan Quan , Yuanan Chen , Qin Wang , Xiaoxing Zou , Fangyou Chen and Lin Ni

A new lignan, 4,4²-dihydroxy-3,3¢,5¢,3²,5²,7²-pentamethoxy-7,9¢;7¢,9-diepoxy-4¢,8²-oxy-8,8¢-sesquineo-lignan-propanol (1), along with six known lignans (2-7) was isolated from the leaves of Ormosia xylocarpa (Chun ex L. Chen). The structure of compound 1 was elucidated through comprehensive 1D and 2D NMR, UV, IR, and HRMS analyses. Compounds 2~3 performed strong antioxidant activity, the median clearance concentration of DPPH, ABST+, and ·OH was lower than 40 μM.

DOI
http://doi.org/10.25135/rnp.338.2203.2386
Keywords
Ormosia xylocarpa lignans chemical constituents antioxidant activity
Available online: July 11, 2022
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Original Article

19) The Effect of Cynara cornigera L. in HepG2 Hepatocellular Carcinoma Cells

Rec. Nat. Prod. (2022) in press ; 1 - 13
by Erdal Sanlidag , Eda Becer , İhsan Çalış , Kemal H. C. Baser , Azmi Hanoğlu , Fatih Göger and H. Seda Vatansever

Amongst all cancer types, liver cancer is the fourth leading cause of cancer mortality. It is frequently stated as hepatocellular carcinoma (HCC) and occurs in hepatocytes. Genetic alterations of hepatocytes such as Wnt/β-catenin and JAK / STAT signaling pathways play a key role for the development of the HCC. Currently, there are a few available treatments for HCC; such treatments include transplantation, surgical resections and anticancer drugs. Most of the anti-cancer drugs target the signaling pathways for achieving an effective treatment. However, these treatments have some undesirable side effects. Thus, there is a need for discovering alternative anti-cancer agents with no or lesser side effects. Plant constituents are promising anti-cancer agents. Cynara cornigera L. contains plenty of phenolic compounds including quercetin, apigenin, etc. This study aimed to analyze the anti-cancer property of the fractionated methanol extract of the flowers of C. cornigera. All the fractions obtained were analyzed to determine the cytotoxic activity on HepG2 cells. Two of the fractions containing polyphenolic compounds had a significant cytotoxic activity related to non-canonical Wnt11 signaling pathways on HepG2 cells.

DOI
http://doi.org/10.25135/rnp.335.2106.2092
Keywords
Cynara cornigera phenolic compounds HepG2 HepG2 Wnt11 liver cancer
Available online: July 04, 2022
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Short Report

20) Psammosilenin C, a New Cyclic Peptide from Psammosilene tunicoides

Rec. Nat. Prod. (2022) in press ; 1 - 5
by Xiuxia Yang , Xishan Bai , Hongrui Li , Jingxian Sun , Yong Xiong , Yanhong Li and Xiangzhong Huang

Phytochemical investigation of Psammosilene tunicoides led to isolation of a new cyclic peptide, psammosilenin C (1) and three known compounds, 1-O-(β-D-glucopyranosyl)-(2S,3R,4E,8E)-2-[(2R)-2-hydroxypentadecanoylamino]-4,8-octadecadiene-1,3-diol (2), dihydroferulic acid (3) and vanillylacetone (4). Their structures were elucidated by comprehensive spectroscopic methods, including 1D and 2D NMR spectroscopic, and HR-ESI-MS spectrometric data. Compounds 1, 2 and 4 showed inhibitory activities on lipopolysaccharide (LPS)-induced NO release in RAW 264.7 cells.

DOI
http://doi.org/10.25135/rnp.336.2203.2399
Keywords
Psammosilene tunicoides cyclic peptide anti-inflammatory activity
Available online: June 21, 2022
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Original Article

21) In Silico Study of Natural Xanthones as Potential Inhibitors of Alpha-Glucosidase and Alpha-Amylase

Rec. Nat. Prod. (2022) in press ; 1 - 20
by Michaella Yosephine , Isa Anshori , Muhammad Miftah Jauhar , Putri Hawa Syaifie , Adzani Gaisani Arda , Azza Hanif Harisna , Dwi Wahyu Nugroho and Etik Mardliyati

Type 2 diabetes mellitus is a disease caused by insulin resistance. Many types of oral medications exist, but the effectiveness and side effects differ from patient to patient, so alternative drugs are still required. One compound group receiving much scientific interest regarding its antidiabetic potential is xanthones as potential alpha-glucosidase and alpha-amylase inhibitors. This study performed molecular docking simulations on all 515 natural xanthones with alpha-glucosidase and alpha-amylase as the protein targets. We found 31 unique ligands that comply, and the three best ligands per protein target were filtered based on how many active site residues the ligands interacted with the targets. The three best alpha-glucosidase inhibitors are 3,4,5,8-tetrahydroxy-1,2-diisoprenylxanthone, Polygalaxanthone V, and Polygalaxanthone VII. As for alpha-amylase, we found 1-O-primeverosyl-3,8-dihydroxy-5-methoxyxanthone, Garcimangosone C, and Mangostinone as the best inhibitors. The six chosen and standard ligands underwent 2 ns molecular dynamics simulations. Both standard ligands had the highest interaction energies, followed by complexes with glycosylated xanthones, and prenylated xanthones. We also found that the prenylated xanthones could retain their initial protein-ligand interactions. Therefore, this is the first study that revealed prenylated xanthones have a good potential as anti-type 2 diabetes mellitus agents among other xanthones groups through in silico method.

DOI
http://doi.org/10.25135/rnp.337.2203.2391
Keywords
Molecular docking molecular dynamics xanthone alpha-amylase inhibitor alpha-glucosidase inhibitor
Available online: June 21, 2022
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Original Article

22) The Essential Oil Compositions of Teucrium spp. Belonging to the Section Polium Schreb. (Lamiaceae) Growing in Cyprus

Rec. Nat. Prod. (2022) in press ; 1 - 12
by Duygu Yigit Hanoğlu , Azmi Hanoğlu , Betül Demirci and Kemal Hüsnü Can Başer

The genus Teucrium L., belonging to the family Lamiaceae, is divided in ten sections including Polium (Mill.) Schreb. In Cyprus, this section is represented by five endemic species: T. micropodioides, T. cyprium, T. karpasiticum, T. kyreniae and T. salaminium. Essential oils of the aerial parts of these species were separately obtained by hydrodistillation using a Clevenger-type apparatus. Chemical compositions of the obtained oils were analyzed by GC and GC/MS, simultaneously. The essential oil yields ranged between 0.03-0.75 (v/w). The major components of the essential oil of T. kyreniae were β-caryophyllene (21.2%), (Ε)-nerolidol (10.9%), carvone (8.8%) and α-humulene (7.9%). T. salaminium essential oil was dominated by β-caryophyllene (15.2%), caryophyllene oxide (13.9%), germacrene D (11.6%) and bicyclogermacrene (10.0%). Major components of the oil of T. cyprium were β-pinene (35.4%), α-pinene (10.6%) and spathulenol (8.4%). Major compounds of the oils of T. micropodioides samples, collected from two different locations, were (1) limonene (47.0%), β-pinene (16.0%) and β-caryophyllene (6.9%), (2) δ-cadinene (11.2%), 1-epi-cubenol (7.8%), cubebol (4.7%), cubenol (4.1%), respectively. Main constituents of the essential oil of T. karpasiticum were limonene (43.9%), β-pinene (16.0%), α-bisabolol oxide A (7.8%), β-caryophyllene (5.5%) and α-pinene (4.6%). The section Polium, is considered a complex and the diversity of oil compositions from the species belonging to this section provided additional proof to this consideration.

DOI
http://doi.org/10.25135/rnp.327.2203.2379
Keywords
Lamiaceae Section Polium Teucrium spp. Cyprus Endemic Essential oil
Available online: June 06, 2022
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Short Report

23) A New Megastigmane Glycoside and Other Constituents from Amomum muricarpum Elmer

Rec. Nat. Prod. (2022) in press ; 1 - 6
by Tran Thi Thu Phuong , Nguyen Hai Dang , Nguyen Thi Hong Anh , Do Hoang Giang and Dat Nguyen Tien

An updated phytochemical investigation of the aerial parts of Amomum muricarpum Elmer led to the isolation of a new megastigmane glycoside, (3S*,5R*,6R*,9R*)-6,9-epoxy-3,5-megastigmanediol 3-O-rutinoside (1) and five known phenolic compounds. Their structures were elucidated by spectroscopic evidence including HRESIMS and NMR data. All the isolates were reported for the first time from this plant. The anti-inflammatory effect via the inhibition of NO production of isolated compounds was evaluated in LPS-stimulated RAW 264.7 cells. Our study found that 5,7-dimethoxyflavone (4) was the most active compound with the IC50 = 29.5 µM.

DOI
http://doi.org/10.25135/rnp.333.2203.2395
Keywords
Amomum muricarpum megastigmane 5,7-dimethoxyflavone anti-inflammation
Available online: June 06, 2022
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Original Article

24) First 6, 7-Seco-Clerodane Furan Diterpenoid from Croton morifolius

Rec. Nat. Prod. (2022) in press ; 1 - 7
by René Velázquez-Jiménez , Alejandra Hernández-Sosa , Diego Martínez-Otero , Simplicio González-Montiel , Irais Sánchez-Ortega and César A. González -Ramírez

A novel 6,7-seco-clerodane furan-diterpenoid, named as Morifolin A, was obtained from Croton morifolius. The molecular structure of Morifolin A was determined by 1D/2D NMR spectroscopy, mass spectrometry and single-crystal X-ray diffraction analysis (Cu Kα). Morifolin A contains one furan ring bridged to a cyclohexene ring via an alkenyl chain and its crystal packing is displaying intermolecular interactions as C−H⋯O.

DOI
http://doi.org/10.25135/rnp.332.2204-2422
Keywords
Croton morifolius 6,7 seco-clerodane furan-diterpenoid Morifolin A absolute configuration X-ray diffraction
Available online: June 02, 2022
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Short Report

25) Bioactive Alkaloids from the Beibu Gulf Coral-associated Fungus Acremonium sclerotigenum GXIMD 02501

Rec. Nat. Prod. (2022) in press ; 1 - 5
by Bingyao Huang , Humu Lu , Yanting Zhang , Xia Gan , Xueni Wang , Yong-Hong Liu and Xiaowei Luo

The Beibu Gulf represents an underexplored reservoir of marine micro-/organisms and secondary metabolites. Three uncommon 4-hydroxy-2-pyridone alkaloids and one phenazine alkaloid were obtained from the Beibu Gulf coral-associated fungus Acremonium sclerotigenum GXIMD 02501 via OSMAC approach. They were identified as campyridones D (1) and A (2), ilicicolin H (3), and phenazine-1-carboxylic acid (4), respectively, by spectroscopic analysis and comparison with literature values. All of them were evaluated for cytotoxic, anti-Vibrio, and NF-κB luciferase inhibitory activities. Compounds 2 and 3 showed cytotoxicity against two prostate cancer cell lines, with IC50 values of 17.6 ± 1.3 and 5.5 ± 1.2 μM for PC-3, while 25.4 ± 1.7 and 11.9 ± 1.3 μM for 22Rv1, respectively. Besides, compound 4 showed promising anti-Vibrio activity with MIC values of 0.047–0.067 mg/mL and also displayed inhibition of LPS-induced NF-κB activation at 10 μM.

DOI
http://doi.org/10.25135/rnp.329.2204.2437
Keywords
Acremonium sclerotigenum coral-associated fungi alkaloids bioactivity cytotoxicity
Available online: May 22, 2022
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Short Report

26) Three New Chromone Derivatives from the Deep-Sea-Derived Fungus Penicillium thomii

Rec. Nat. Prod. (2022) in press ; 1 - 5
by Fan Yang , Yu Liu , Xiaoqian Zhang , Wan Liu , Ying Qiao , Wei Xu , Qin Li and Zhongbin Cheng

Chemical investigation of the EtOAc extract of a deep-sea-derived fungus Penicillium thomii Maire YPGA3 cultured on rice solid medium led to the isolation of three new chromone analogs, named penithochromones U-W (1-3), along with six known compounds (4-9). The structures were determined by extensive analyses of spectroscopic data (NMR and HRESIMS data). Compounds 1-3 are 5,7-dioxygenated chromone analogs bearing an aliphatic acid side chain. All isolated compounds were inactive toward the a-glucosidase at the concentration of 200 mM.

DOI
http://doi.org/10.25135/rnp.330.2204.2433
Keywords
Penicillium thomii; deep-sea fungus chromone derivative chromone derivative penithochromone
Available online: May 22, 2022
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Short Report

27) Furan Derivatives and Amides from Elaeocarpus apiculatus

Rec. Nat. Prod. (2022) in press ; 1 - 4
by Shen Yao and Xinyi Yang

The first phytochemical study of Elaeocarpus apiculatus led to the isolation of five compounds, including two furan derivatives (1 and 2) and three amides (3-5). Among them, compound 1 was a new furan derivative, and compounds 2-5 were discovered from the genus Elaeocarpus for the first time. The characterization of these compounds was achieved by HRMS, UV, IR and NMR data. Compounds 1, 3 and 4 showed weak nitric oxide (NO) inhibitory effects. A potential biogenetic pathway for the formation of 1 was proposed.

DOI
http://doi.org/10.25135/rnp.331.2203.2376
Keywords
Elaeocarpus apiculatus Elaeocarpaceae furan derivative amide
Available online: May 19, 2022
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Original Article

28) Secondary Metabolites with Antioxidant and Mushroom Tyrosinase Inhibitory Activities from Ajuga nipponensis

Rec. Nat. Prod. (2022) in press ; 1 - 7
by Na Sun , Tingting Du , Yifang Zhang , Yiming Luo , Xinyu Ma , Ru Zhang , Xinru Wu , Huanhuan Yang , Miao Zhou , Penghua Shu and Jihong Huang

One neo-clerodane diterpenoid (1), two abietane diterpenoids (2 and 3), three flavonoids (36), one C6-substituted chromone derivative (7), one phenylpropanoid (8), as well as one chain fatty acid (9) were isolated from the whole plants of Ajuga nipponensis. Their structures were established by detailed analysis of the HRESIMS, 1D and 2D NMR, UV, and IR. The absolute configuration of compound 1 was firstly determined by ECD calculation and single crystal diffraction. The NMR data of compound 9 are reported for the first time. Compounds 4, 79 were isolated from this medicinal plant for the first time, and 4, 9 were first discovered from natural products. The isolates 17 were tested for their antioxidant and mushroom tyrosinase inhibitory activities. Most of them showed moderate antioxidant activities. Compounds 1, 4, 5, and 7 exhibited obvious antioxidant activities at 50 μM, with % inhibition values of 32.37±0.75%, 25.30±0.66%, 28.76±0.64%, 31.06±0.46%, respectively, with L-ascorbic acid used as the positive control (71.29±0.34%). Compound 7 exhibited significant inhibitory activities against mushroom tyrosinase (%inhibition values of 16.94±1.28%), with arbutin used as the positive control (29.9±0.99%).

 

DOI
http://doi.org/10.25135/rnp.321.2201.2330
Keywords
Ajuga L Ajuga nipponensis diterpenoid flavonoid antioxidation tyrosinase inhibitory activity
Available online: May 07, 2022
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Original Article

29) A Novel Cyclohexane Carboxylic Acid Derivative from Black Turtle Bean (Phaseolus vulgaris L.)

Rec. Nat. Prod. (2022) in press ; 1 - 6
by Balkisu Abdulrahman , Fadime Aydogan , Fazila Zulfiqar , Jianping Zhao , Zulfiqar Ali , Ikhlas A. Khan , Bala Muntari and Oluwasesan Bello

Abstract: Black turtle bean is a variety of Phaseolus vulgaris L. in the legume family Fabaceae and is consumed as food worldwide. A targeted phytochemical investigation of the ethanolic extract of its seeds, focusing on constituents other than the lipophilic metabolites, resulted in the isolation and characterization of five compounds (1-5). Compound 1 (phasvulic acid), a previously undescribed cyclohexane carboxylic acid derivative, was characterized as (Z)-3-hydroxy-2-(5-hydroxypent-2-en-1-yl)cyclohexane-1-carboxylic acid based on spectral data including 1D and 2D NMR (1H, 13C, COSY, HSQC, and HMBC) and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). Other compounds were formerly described as dihydrophaseic acid (2), uridine (3), stigmasterol-3-O-β-D glucopyranoside (4), and β-sitosterol-3-O-β-D-glucopyranoside (5).

DOI
http://doi.org/10.25135/rnp.325.2202.2361
Keywords
Black turtle bean Phaseolus vulgaris phasvulic acid legume Fabaceae
Available online: May 05, 2022
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Review Article

30) Ethnobotanical Records of Medicinal Plants of Turkey Effective on Stress Management Complied with the Literature Survey in Their Chemical Content and Activities

Rec. Nat. Prod. (2022) in press ; 1 - 92
by Fatma Memnune Erucar , Nur Tan and Mahmut Miski

The increase of challenges in people's lives, daily problems as well as traumatic events could lead them to experience stress. Because of the side effects of current drugs, the recent medications are not sufficient to cure stress-related diseases; new approaches are needed in order to find more effective medications with fewer side effects. Ethnobotanical and ethnomedical research is increasingly recognized as a viable source of data and plausible pharmacological action of many plants. The review presents ethnobotanical information of the plants which have been used against stress-related diseases among local people of Turkey.  In addition, a survey of the current literature on the topic aims to find new natural resources that will contribute to the development of drugs and bring them to the literature by scanning the scientific articles on the isolation and structure determination of the secondary metabolites of these medicinal plants, which have been already in use among the public for stress-related disorders for centuries. This research is not only the first step in the research of promising new compounds against stress but it is also a presentation of data on medicinal plants of Turkey: Their medicinal parts, method of preparation, usage patterns and, if recorded, their dosages.

DOI
http://doi.org/10.25135/rnp.324.2203.2372
Keywords
Stress herbal drugs ethnobotanical
Available online: May 03, 2022
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