Trichothecene Sesquiterpenes with Anti-osteosarcoma Cytotoxicity from the Fungus Fusarium sp. XPW68

Short Report

JOURNAL 3479

Records of Natural Products
VOLUME & ISSUE
Available Online: May 22,2025
PAGES
p.11 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.519.25.04.3479
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Huihuang Peng
  • Rui Chen
  • Yanxia Zhang
  • Linsa Zhou
  • Jie Lin
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Fusarinene A (1), a previously undescribed trichothecene sesquiterpene, and three known compounds, 4β-hydroxytrichotheca-9,12-diene (2), trichodermol (3), and trichodermin (4), were isolated from the extract of Fusarium sp. XPW68. Their structures and relative configurations were identified by detailed analysis of nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HRESIMS) data. In the cytotoxic assay, compounds 1-4 exhibited selective or potent inhibition against five human osteosarcoma cell lines including 143B, MG-63, SaOS-2, SW1353, and U2OS, with IC50 values ranging from 0.8 to 48.2 μM.

 

 

 KEYWORDS
  • Fusarium
  • trichothecene sesquiterpene
  • structure elucidation
  • cytotoxic activity

SUPPORTING INFORMATION

Supporting Information
Download File 519-RNP-2504-3479-SI.pdf (286.74 KB)