In vitro antiproliferative activity of some fluoro-substituted benzimidazole-based scaffolds

Original Article

JOURNAL 2065

Bioorganic and Medicinal Chemistry Reports

VOLUME & ISSUE

Year: 2021 Issue: 1 January-June

PAGES

p.10 - 17

DOI ADDRESS

http://doi.org/10.25135/acg.bmcr.25.21.05.2065

STATISTICS

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AUTHORS

Ronak Haj Ersan
Nizami Duran

GRAPHICAL ABSTRACT

ABSTRACT

In the present work, a series of fluoro-substituted benzimidazole derivatives were designed and synthesized as antiproliferative agents. The antiproliferative activity of these compounds was investigated using MTT assay. Fluoro-substituted benzimidazole derivatives showed significant antiproliferative activity against all the tested cancer cell lines. All the derivatives were found to be less toxic as compared to methotrexate (positive control) in human cells, indicating selective and efficient antiproliferative activity of these benzimidazole derivatives. These findings suggest that compounds ORT14 and ORT15 among this series are most effective and have potential for detailed investigations.

KEYWORDS

Benzimidazole
fluorine
antiproliferative
anticancer
SAR