JOURNAL 2065


Bioorganic and Medicinal Chemistry Reports
VOLUME & ISSUE
Year: 2021 Issue: 1 January-June
PAGES
p.10 - 17
STATISTICS
Viewed 26 times.
AUTHORS
  • Ronak Haj Ersan
  • Nizami Duran
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


In the present work, a series of fluoro-substituted benzimidazole derivatives were designed and synthesized as antiproliferative agents. The antiproliferative activity of these compounds was investigated using MTT assay. Fluoro-substituted benzimidazole derivatives showed significant antiproliferative activity against all the tested cancer cell lines. All the derivatives were found to be less toxic as compared to methotrexate (positive control) in human cells, indicating selective and efficient antiproliferative activity of these benzimidazole derivatives. These findings suggest that compounds ORT14 and ORT15 among this series are most effective and have potential for detailed investigations.

KEYWORDS
  • Benzimidazole
  • fluorine
  • antiproliferative
  • anticancer
  • SAR