JOURNAL 2418


Bioorganic and Medicinal Chemistry Reports
VOLUME & ISSUE
Year: 2022 Issue: 1 January-June
PAGES
p.9 - 19
STATISTICS
Viewed 96 times.
AUTHORS
  • Alptuğ Atila
  • Yücel Kadioglu
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


In the present study, GC-FID method for the determination of lidocaine HCl in commercially creams and injection forms was developed and validated. The linearity of method was observed in the concentration range of 0.1-5.0 µg/mL. The accuracy (RE%) and precision (RSD%) values of the within-day and between-day of GC-FID method are less than 10.0% and 3.0%, respectively, and also limit of detection (LOD)  and the limit of quantitation (LOQ) values  were observed as 0.03 and 0.11 µg/mL, respectively. The analytical recovery value of lidocaine HCl was determined as 99.47% on average. As a result, it was concluded that the developed and validated GC-FID method can be easily used in routine analyzes in quality control laboratories.  

KEYWORDS
  • Lidocaine HCl
  • local anesthesia
  • cream
  • injection
  • GC-FID Method