JOURNAL 2418
Bioorganic and Medicinal Chemistry Reports
VOLUME & ISSUE
Year: 2022 Issue: 1 January-June
Year: 2022 Issue: 1 January-June
PAGES
p.9 - 19
p.9 - 19
STATISTICS
Viewed 1594 times.
Viewed 1594 times.
GRAPHICAL ABSTRACT
ABSTRACT
In the present study, GC-FID method for the determination of lidocaine HCl in commercially creams and injection forms was developed and validated. The linearity of method was observed in the concentration range of 0.1-5.0 µg/mL. The accuracy (RE%) and precision (RSD%) values of the within-day and between-day of GC-FID method are less than 10.0% and 3.0%, respectively, and also limit of detection (LOD) and the limit of quantitation (LOQ) values were observed as 0.03 and 0.11 µg/mL, respectively. The analytical recovery value of lidocaine HCl was determined as 99.47% on average. As a result, it was concluded that the developed and validated GC-FID method can be easily used in routine analyzes in quality control laboratories.
KEYWORDS- Lidocaine HCl
- local anesthesia
- cream
- injection
- GC-FID Method