JOURNAL 3509
Bioorganic and Medicinal Chemistry Reports
VOLUME & ISSUE
Year: 2025 Issue: 1 January-June
Year: 2025 Issue: 1 January-June
PAGES
p.1 - 9
p.1 - 9
STATISTICS
Viewed 11 times.
Viewed 11 times.
AUTHORS
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Madhava Rao Vallabhaneni
-
Srinivasa Rao Nathani
-
Lakshmi Kondraganti
-
Hanumatha Rao Addanki
-
Sudheer Chowdary Bodempudi
GRAPHICAL ABSTRACT

ABSTRACT
2-Styrylchromones are very potent bioactive substances showing innumerable activities like antioxidant, antidiabetic, antiviral, antiinflammatory, anticancer, anti-microbial etc. All these activities are due to their core structure (benz-γ-pyrone) containing styryl group at 2nd position. Substituents especially hydroxyl groups are responsible for anti-diabetic and antioxidant activities. 2-Styrylchromones with a greater number of –OH substituents showed high activity than the remaining compounds. Compounds 5, 6, 7 and 9 having significant activity where the nature and position of substituents play a vital role. The synthetic compound with –OH groups at 4', 6 and 7 positions competed with standard drugs in respective activities.
KEYWORDS- 2-styrylchromones
- antidiabetic Activity
- antioxidant Activity
- streptozotocin induced diabetic
- glibenclamide
- superoxide radical scavenging