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Antidiabetic and antioxidant activities of synthetic 2-styrylchromones

Original Article

JOURNAL 3509

Bioorganic and Medicinal Chemistry Reports
VOLUME & ISSUE
Year: 2025 Issue: 1 January-June
PAGES
p.1 - 9
DOI ADDRESS
doi.org/10.25135/bmcr.33.2505.3509
STATISTICS
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AUTHORS
  • Madhava Rao Vallabhaneni
  • Srinivasa Rao Nathani
  • Lakshmi Kondraganti
  • Hanumatha Rao Addanki
  • Sudheer Chowdary Bodempudi
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

2-Styrylchromones are very potent bioactive substances showing innumerable activities like antioxidant, antidiabetic, antiviral, antiinflammatory, anticancer, anti-microbial etc. All these activities are due to their core structure (benz-γ-pyrone) containing styryl group at 2nd position. Substituents especially hydroxyl groups are responsible for anti-diabetic and antioxidant activities. 2-Styrylchromones with a greater number of –OH substituents showed high activity than the remaining compounds. Compounds 5, 6, 7 and 9 having significant activity where the nature and position of substituents play a vital role. The synthetic compound with –OH groups at 4', 6 and 7 positions competed with standard drugs in respective activities.

 KEYWORDS
  • 2-styrylchromones
  • antidiabetic Activity
  • antioxidant Activity
  • streptozotocin induced diabetic
  • glibenclamide
  • superoxide radical scavenging

SUPPORTING INFORMATION

Supporting Information
Download File 33-BMCR-2505-3509-SI.pdf (728.84 KB)