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Synthesis, Spectral characterization and antimicrobial activity of 2-(substituted)-2,2-[1,3- dihydro-(3,4-1,2,5-oxadiazolediyl) diaza][5 ׳ , 5 ׳ -dimethyl-1 ׳ , 3 ׳ -propanediyl) dioxy] phosphoranes

Original Article

JOURNAL 162

Organic Communications
VOLUME & ISSUE
Year: 2010 Issue: 1 January-March
PAGES
p.15 - 21
STATISTICS
Viewed 1960 times.
AUTHORS
    Synthesis, Spectral characterization and antimicrobial activity of 2-(substituted)-2,2-[1,3- dihydro-(3,4-1,2,5-oxadiazolediyl) diaza][5 ׳ , 5 ׳ -dimethyl-1 ׳ , 3 ׳ -propanediyl) dioxy] phosphoranes
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GRAPHICAL ABSTRACT

ABSTRACT

The cyclic oxadiazolediyl dioxachlorophosphine precursor on subsequent reaction with various alcohols underwent halide displacement to give 2-substituted diaza phospholes. These phospholes on oxidative addition with di hydroxy alcohols form corresponding phosphoranes The antimicrobial activities of these compounds were evaluated and they exhibited significant antimicrobial activity.

 KEYWORDS
  • Spirophosphoranes
  • dioxaphosphoranes
  • antimicrobial activity
  • P(III) to P(V)
  • N-chlorodiisopropylamine.