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Synthesis and antimicrobial evaluation of 2-(2-butyl- 4-chloro-1H-imidazol-5-yl-methylene)-substituted-benzofuran-3-ones

Original Article

JOURNAL 163

Organic Communications
VOLUME & ISSUE
Year: 2010 Issue: 2 April-June
PAGES
p.22 - 29
STATISTICS
Viewed 2228 times.
AUTHORS
    Bhaskar S. Dawane, Shankaraiah G. Konda, Namdev T. Khandare, Santosh S. Chobe, Baseer M. Shaikh, Ragini G. Bodade and Vishwas D. Joshi
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GRAPHICAL ABSTRACT

ABSTRACT

In the present study, the oxidation of 3-(4-chloro-1H-imidazol-5-yl)-1-(2-hydroxyphenyl)prop-2-en-1-ones with mercuric(II) acetate in in polyethylene glycol (PEG-400) gave the corresponding 2-((4-chloro-1H-imidazol-5-yl)methylene)benzofuran-3(2H)-ones. Newly synthesized compounds were tested for their in vitro antimicrobial activity.

 KEYWORDS
  • PEG-400
  • 2’-hydroxy chalcones
  • benzofuran-3-ones
  • antimicrobial activity.