Glycerin as alternative solvent for the synthesis of Thiazoles

Original Article

JOURNAL 185

Organic Communications

VOLUME & ISSUE

Year: 2011 Issue: 3 July-September

PAGES

p.75 - 81

STATISTICS

Viewed 2692 times.

AUTHORS

A. Venkat Narsaiah, Ramesh S. Ghogare and Dhanraj O. Biradar .

GRAPHICAL ABSTRACT

ABSTRACT

A variety of α-bromoketones undergoes smooth condensation with thiourea/ thioamide compounds to afford the corresponding substituted thiazole derivatives in excellent yields. The condensation reactions were carried out in a recyclable reaction medium glycerin without using any catalyst. All the reactions were completed within 2 hours of reaction time at room temperature.

KEYWORDS

Bromo ketone
thiourea
urea
thiazole
catalyst-free
glycerin.