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Iodine-catalyzed addition of 2-mercaptoethanol to chalcone derivatives: Synthesis of the novel β-mercapto carbonyl compounds

Original Article

JOURNAL 1704

Organic Communications
VOLUME & ISSUE
Year: 2012 Issue: 2 April-June
PAGES
p.70 - 76
STATISTICS
Viewed 1647 times.
AUTHORS
    Gürkan Yerli, Hayreddin Gezegen and Mustafa Ceylan
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

In this study, a series of novel β-mercapto carbonyl derivatives (3-(2-hydroxyethylthio)-1,3- diarylpropan-1-one) (5a-i) were prepared by addition of 2-mercaptoethanol (4) to chalcones (3a-i) in the presence of catalytic amount of iodine (10 mol %) in CH2Cl2.

 KEYWORDS
  • Chalcone
  • 2-mercaptoethanol
  • iodine
  • Thia-michael addition
  • β-mercapto carbonyl.