Stereoselective synthesis of tuberculostatic agent (S,S)-ethambutol

Original Article

JOURNAL 676

Organic Communications

VOLUME & ISSUE

Year: 2014 Issue: 1 January-March

PAGES

p.28 - 33

STATISTICS

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AUTHORS

J. Kranthi Kumar and A. Venkat Narsaiah

GRAPHICAL ABSTRACT

ABSTRACT

A simple and efficient asymmetric synthesis of (S,S)-Ethambutol has been carried out using a chiral butanediol. The synthesis was completed within six steps with an overall yield 53% and the enantiomeric purity of final product was 98%. All the reactions were very clean and the yields are excellent.

KEYWORDS

Ethambutol
butanediol
protection
tuberculosis
oxalylchloride
reduction