Synthesis of thioalkylated-4-aryltetrahydroquinazolinone derivatives and their antibacterial activity

A series of 2-[2-oxo-2-(2-oxo-2H-chromen-3-yl)-ethylsulfanyl]-4-aryl-4,6,7,8-tetrahydro-3H-quinazolin-5-ones (7a-f) and 2-[2-oxo-2-(3-oxo-3H-chromen-2-yl)-ethylsulfanyl]-4-aryl-4,6,7,8-tetrahydro-3H-quinazolin-5-ones (9a-f) were synthesized and screened for their in vitro antibacterial activity against Staphylococcus aureus, Bacillus thuringiensis (Gram positive) , Escherichia coli and Klebsiella pneumonia (Gram negative) bacterial strains . Among all the compounds, 7b and 7d were shown highest activity against all the tested bacterial strains compared to the standard drug Gentamicin. These two quinazolinone derivatives (7b and 7d) could be considered as useful templates for further development of potential antibacterial agents.