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Synthesis and antioxidant activity of dioxazaphosphinin-2-ones

Original Article

JOURNAL 769

Organic Communications
VOLUME & ISSUE
Year: 2015 Issue: 1 January-March
PAGES
p.17 - 23
STATISTICS
Viewed 2583 times.
AUTHORS
    N. Bakthavatchala Reddy, Ch. Syama Sundar, S. H. Jayaprakash, G. Mohan, P. Vasugovardan Reddy and C. Suresh Reddy
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GRAPHICAL ABSTRACT

ABSTRACT

A simple and efficient synthesis of dioxazaphosphinin-2-ones has been developed by the cyclisation of 2-hydroxy-1,2-diphenylethanoneoxime with phosphorus oxychloride in the presence of triethylamine in dry THF to afford the corresponding monochloride. In the next step, subsequent reaction of monochloridewith different amines at 50-60 ˚C for 2-3 hours resulted in the formation of the title compounds (4a-j). The lead compounds were screened for their antioxidant activity.

 KEYWORDS
  • 2-hydroxy 1
  • 2-diphenylethanoneoxime
  • POCl 3
  • dioxazaphosphinin-2-ones
  • Antioxidant activity