Microwave assisted synthesis and antimicrobial activity of novel 1-[1/2-(1-Benzyl-1H-[1,2,3]triazol-4-ylmethoxy)-naphthalen-2/1-yl]-3-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-propenones

Original Article

JOURNAL 770

Organic Communications

VOLUME & ISSUE

Year: 2015 Issue: 2 April-June

PAGES

p.24 - 35

STATISTICS

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AUTHORS

Dongamanti Ashok,Marc Lecouvey, Houria Berrebah and Nour-Eddine Aouf

GRAPHICAL ABSTRACT

ABSTRACT

A series of novel 1-[1/2-(1-Benzyl-1H-[1,2,3]triazol-4-ylmethoxy)-naphthalen-2/1-yl]-3-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-propenones were design and synthesized by Click reaction followed by Claisen-Schmidt condensation under microwave irradiation and conventional heating methods. The structures of newly synthesized compounds have been established on the basis of elemental analysis, IR, 1H & 13C NMR and mass spectral data. All the compounds were screened for their antimicrobial activity.

KEYWORDS

1
2
3-triazole
pyrazoles
chalcones
antimicrobial activity
microwave irradiation