JOURNAL 774


Organic Communications
VOLUME & ISSUE
Year: 2015 Issue: 3 July-September
PAGES
p.24 - 35
STATISTICS
Viewed 2371 times.
AUTHORS
    P. Md. Khaja Mohinuddin, Bodireddy Mohan Reddy, G. Trivikram Reddy and N. C. Gangi Reddy
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A simple, regioselective and green method has been developed for the preparation of monobrominated ketones from various aralkyl ketones by using N-bromosuccinimide in presence of KH 2PO 4 in EtOH at reflux temperature. The present method is of short reaction time and simple with excellent isolated yields of products. The use of eco-friendly solvent, reuse of organic waste (succinimide) and recyclable catalyst used for 4 times without loss of activity are advantageous. This is the first example of the use of KH 2PO 4 as a useful catalyst in organohalogen chemistry and the present method meets reduce-reuse-recycle (RRR) principle towards development of green protocol.

KEYWORDS
  • Regioselectivity
  • bromination
  • ketones
  • KH 2PO 4
  • Heterogeneous catalysis
  • Green method