Stereoselective synthesis of C1-C24 fragment of antanapeptin-A

Original Article

JOURNAL 779

Organic Communications

VOLUME & ISSUE

Year: 2016 Issue: 1 January-March

PAGES

p.1 - 18

STATISTICS

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AUTHORS

Srinivas Avula, Sunitha Malladi and Rajesh Kumar Gaddam

GRAPHICAL ABSTRACT

ABSTRACT

The stereoselective synthesis of the (C1-C24) fragment of Antanapeptin–A is described. The required stereochemistry of b -hydroxy- a -methyl acid unit was accomplished through Aldol reaction using Evans’ chiral auxiliary followed by the installation of terminal alkyne with Ohira–Bestmann reagent.

KEYWORDS

Antanapeptin A
Aldol Reaction
Stereo selective synthesis
Peptide
Evans’ auxiliary