JOURNAL 787


Organic Communications
VOLUME & ISSUE
Year: 2016 Issue: 4 October-December
PAGES
p.73 - 81
STATISTICS
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AUTHORS
    Ahmet Yaşar, Nevin Ulaş and Sercan Yıldırım
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GRAPHICAL ABSTRACT


ABSTRACT


2′-Azaflavonone (6) and 3′-azaflavonone (7); were synthesized by a simple environmentally friendly microwave-assisted one-pot method for the cyclization of 2′-hydroxy β′-2-azachalcanon-β-ol (1), 2′-hydroxy (E)-2-azachalcone (2), 2′-hydroxy (E)-3-azachalcone (3) under solventless conditions using K-10 clay. In addition to these synthesis, 3-(pyridin-2-yl methyl)-2′-azaflavone (8) and 3-(pyridin-3-yl methyl)-3′-azaflavone (9) were synthesized using silica-supported sodium hydrogen sulphate then the treatment with base, respectively. Additionally, for antimicrobial activities N-alkyl substituted 3′-azaflavonium and 2′-azaflavonium bromides (10-12) were prepared from compounds 34 - 5 and 8 - 9.

KEYWORDS
  • Azaflavone
  • azaflavonone
  • microwave
  • azachalcone