Synthesis of new potential Indole-3-yl derivatives via Knoevenagel condensation

A variety of 1-acetyl-1H-indol-3-yl derivatives have been prepared from indole-3-carboxaldehyde. By knoevenagel reaction between indole-3-carboxaldehyde and active methylene or non-active methylene compounds yielded the coresponding condensation product, indole-3-yl derivatives (2a-e) and then their N-acetylation with acetyl chloride afforded N-acetyl-1H-indol-3-yl derivatives (3a-e). 1H-NMR, LC-MS, FT-IR and UV-Visible tools were used to confirm the structures.