Synthesis, spectral characterization and biological activity of N-4-(N-2-(trifluoromethylphenyl))sulfamoyl amide derivatives

Original Article

JOURNAL 789

Organic Communications

VOLUME & ISSUE

Year: 2016 Issue: 4 October-December

PAGES

p.94 - 101

STATISTICS

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AUTHORS

Mavallur Varalakshmi and Chamarthi Nagaraju

GRAPHICAL ABSTRACT

ABSTRACT

Synthesis of a series of new N -4-(N-2-(trifluoromethylphenyl))sulfamoyl amide derivatives 6(a-i) was accomplished by a sequence of reactions by using aniline as a starting compound (1). The newly synthesized compounds were characterized by the spectral analysis and evaluated their antibacterial activity. 5-Nitro-N-(4-(N-(2-(trifluoromethyl)phenyl)sulfamoyl)phenyl)furan-2-carboxamide (6b) exhibited the highest activity.

KEYWORDS

Aniline
trifluoroacetic anhydride
sulfonylchloride
antibacterial activity

SUPPORTING INFORMATION

Supporting Information

Download File 11-OC-1609-436_SI.pdf (226.99 KB)