JOURNAL 809


Organic Communications
VOLUME & ISSUE
Year: 2017 Issue: 2 April-June
PAGES
p.99 - 103
STATISTICS
Viewed 2337 times.
AUTHORS
    Mohd Tajudin Mohd Ali, Siti Aisyah Aliasak and Allan Patrick G. Macabeo
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


This synthetic work reports a concise, asymmetric synthesis of b -amino- g -butyrolactone acetic acid – D-leucine hybrid 1 which will serve as model starting template sub-unit for preparing a/g foldameric oligopeptides containing unnatural g -amino acid residues. The synthesis of cis-substituted 1 was successfully achieved in six linear steps with very good stereoinduction.

KEYWORDS
  • cis- g -butyrolactone
  • foldamer
  • oligopeptide
  • asymmetric epoxide opening
  • g -amino acid