JOURNAL 809
Organic Communications
VOLUME & ISSUE
Year: 2017 Issue: 2 April-June
Year: 2017 Issue: 2 April-June
PAGES
p.99 - 103
p.99 - 103
STATISTICS
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Viewed 2337 times.
GRAPHICAL ABSTRACT
ABSTRACT
This synthetic work reports a concise, asymmetric synthesis of b -amino- g -butyrolactone acetic acid – D-leucine hybrid 1 which will serve as model starting template sub-unit for preparing a/g foldameric oligopeptides containing unnatural g -amino acid residues. The synthesis of cis-substituted 1 was successfully achieved in six linear steps with very good stereoinduction.
KEYWORDS- cis- g -butyrolactone
- foldamer
- oligopeptide
- asymmetric epoxide opening
- g -amino acid