γ-Valerolactone: Promising bio-compatible media for the synthesis of 2-arylbenzothiazole derivatives

Original Article

JOURNAL 1212

Organic Communications

VOLUME & ISSUE

Year: 2019 Issue: 1 January-March

PAGES

p.1 - 13

DOI ADDRESS

http://doi.org/10.25135/acg.oc.54.19.02.1212

STATISTICS

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AUTHORS

Furqan Diwan
Mubarak H. Shaikh
Mohammad Shaikh
Mazahar Farooqui

GRAPHICAL ABSTRACT

ABSTRACT

A new and efficient protocol was developed for synthesis of benzothiazoles as a potential antimicrobial and antioxidant agent using γ-Valerolactone (GVL) as catalyst and solvent under environmentally friendly conditions. The developed synthetic protocol represents a very simple and a novel route for the synthesis of 2-substituted benzothiazole derivatives. In addition, an ultrasound irradiation technique was successfully implemented for performing the reactions in shorter reaction times. The synthesized benzothiazoles were evaluated for antimicrobial and antioxidant activity and was analysed for ADME properties.

KEYWORDS

γ-Valerolactone (GVL)
benzothiazoles
antimicrobial
antioxidant
ADME prediction
ultrasound irradiation

SUPPORTING INFORMATION

Supporting Information

Download File 1-54-OC-1902-1212-SI.pdf (1.35 MB)