JOURNAL 1222
Organic Communications
VOLUME & ISSUE
Year: 2019 Issue: 1 January-March
Year: 2019 Issue: 1 January-March
PAGES
p.38 - 42
p.38 - 42
STATISTICS
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Viewed 2601 times.
GRAPHICAL ABSTRACT
ABSTRACT
In this work, new N-substituted 2-aminopyrrole derivatives were synthesized. Initially, some crotonitriles were prepared by condensation of malononitrile with arylmethylketones, which was followed by conversion of them to the bromocrotonitriles. Finally, the synthesis of new N-substituted 2-aminopyrrole derivates were successfully achieved by cyclization of the bromocrotonitriles of (R)-1-phenylethylamine applying Gewald method.
KEYWORDS
- : Pyrrole
- aminopyrrole
- Knoevenagel condensation
- Gewald reaction
