An efficient and eco-friendly synthesis of 1, 4-dihydropyridines via Hantzsch reaction in Glycine-HCl buffer as solvent and bio-catalyst

Original Article

JOURNAL 1273

Organic Communications

VOLUME & ISSUE

Year: 2019 Issue: 2 April-June

PAGES

p.109 - 114

DOI ADDRESS

http://doi.org/10.25135/acg.oc.58.19.05.1273

STATISTICS

Viewed 2457 times.

AUTHORS

Ali Reza Molla Ebrahimlo
Mounes Hanaforoush
Roya Attari

GRAPHICAL ABSTRACT

ABSTRACT

A green and efficient procedure was established to synthesize 1,4-dihydropyridines via one-pot Hantzsch reactions in buffering conditions without the use of organic solvent. In this method, a buffer solution was used as solvent and catalyst reaction; therefore, using this method has several benefits including high yields, an environmentally friendly procedure, short reaction times, and a simple work-up procedure. All the compounds were characterized by TLC, FT-IR, 1H NMR and elemental studies.

KEYWORDS

Hantzsch reaction
1,4-dihydropyridines
glycine-HCl buffer
green procedure

SUPPORTING INFORMATION

Supporting Information

Download File 58-OC-1905-1273-SI.pdf (1.24 MB)