JOURNAL 1386
Organic Communications
VOLUME & ISSUE
Year: 2019 Issue: 4 October-December
Year: 2019 Issue: 4 October-December
PAGES
p.188 - 201
p.188 - 201
STATISTICS
Viewed 2240 times.
Viewed 2240 times.
GRAPHICAL ABSTRACT
ABSTRACT
A new facile, green and efficient protocol was developed for synthesis of Dihydropyrano [2,3-c] pyrazoles using gluconic acid aqueous solution (GAAS), as catalyst and solvent under environmentally friendly conditions. The advantageous features of this methodology are the environmentally benign character, operational simplicity, high yield processing (91-96%), easy handling; reaction medium can be recycled and reused several times without significant loss of its efficiency. The synthesized compounds were evaluated for antimicrobial and antioxidant activity and also analyzed for ADME properties. The structure of compounds has been confirmed by IR, 1H NMR, 13C NMR, Mass spectrometry and elemental analysis.
KEYWORDS- Dihydropyrano [2,3-c] pyrazoles
- gluconic acid aqueous solution (GAAS)
- green media
- antimicrobial
- antifungal
- antioxidant
