Microvawe assisted synthesis of N-(methyl and methoxy) benzylidene-4-fluoroaniline derivatives and their carbonic anhydrase I and II inhibition properties

Short Communication

JOURNAL 1327

Organic Communications

VOLUME & ISSUE

Year: 2019 Issue: 4 October-December

PAGES

p.210 - 216

DOI ADDRESS

http://doi.org/10.25135/acg.oc.66.19.07.1327

STATISTICS

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AUTHORS

Hülya Çelik
Müslüm Kuzu

GRAPHICAL ABSTRACT

ABSTRACT

IIn this study, some Schiff base derivatives (6a-f) were synthesized using a microwave method. The synthesized compounds were characterized by 1D, 2D NMR and mass spectral data. Their inhibitory effects were studied on carbonic anhydrase isozymes (hCA I and II), purified from human erythrocyte cells by Sepharose-4B-L-tyrosine-sulfanilamide affinity chromatography and the compounds N-3-Methylbenzylidene-4-fluoroaniline (6b), N-4-Methylbenzylidene-4-fluoroaniline (6c), N-2-Methoxybenzylidene-4-fluoroaniline (6d) showed moderate activity on hCAII in the range of IC50 values.

KEYWORDS

Schiff base
carbonic anhydrase
N-benzylideneaniline
NMR
HRMS

SUPPORTING INFORMATION

Supporting Information

Download File A4-66-OC-1907-1327-SI.pdf (1.33 MB)