DBUHI3-catalyzed efficient synthesis of 1,4-dihydropyridines

Original Article

JOURNAL 3780

Organic Communications

VOLUME & ISSUE

Year: 2026 Issue: 1

PAGES

p.2 - 2

DOI ADDRESS

http://doi.org/10.25135/org.2601.3780

STATISTICS

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AUTHORS

Ramesh Gawade
Ravi Varala
Pramod S. Kulkarni

GRAPHICAL ABSTRACT

ABSTRACT

A process-optimized, one-pot multicomponent reaction catalyzed by DBUHI3 was developed, enabling the synthesis of diverse 1,4-dihydropyridines (1,4-DHPs), a class of bioactive nitrogen heterocycles from substituted benzaldehydes, ethyl acetoacetate, and ammonium acetate under mild conditions in DMSO. The methodology afforded good to excellent yields for a variety of aryl aldehyde substrates bearing both electron-donating and electron-withdrawing groups. Structural confirmation was achieved through IR, 1H NMR, 13C NMR, and HRMS analyses. This work not only summarizes key synthetic strategies but also provides a practical, sustainable route to the preparation of 1,4-DHPs, supporting further medicinal and synthetic exploration.

KEYWORDS

1,4-dihydropyridines (1,4-DHPs)
DBUHI3
organocatalyst
multicomponent reaction (MCR)

SUPPORTING INFORMATION

Supporting Information

Download File OC-26013780-SI.pdf (5.18 MB)