Antigenotoxic Activity of Polyphenolic Rich Extracts from Aegle marmelos (L.) Correa in Human Blood Lymphocytes and E.coli PQ 37

The present paper deals with the antigenotoxic activity of Aegle marmelos fruit extracts employing short term assays i.e. the SOS chromotest using Escherichia coli PQ37 and the Comet assay in peripheral human blood lymphocytes. Methanol extract and Acetone extract were quite effective in decreasing the SOS response induced by hydrogen peroxide and aflatoxin B1 in the SOS chromotest. Methanol extract inhibited the genotoxicity of H 2O 2 by 70.48% and that of AFB1 by 84.65%. The extracts showed significant decrease in the tail moment induced by hydrogen peroxide (9 m M) in the Single Cell Gel Electrophoresis (SCGE) assay. The antigenotoxic activity exhibited by the extracts may be attributed the various polyphenolic constituents present in these extracts.