JOURNAL 262


Records of Natural Products
VOLUME & ISSUE
Year: 2009 Issue: 3 July-September
PAGES
p.161 - 164
STATISTICS
Viewed 1767 times.
AUTHORS
    Siddhardha Busi, Prabhakar Peddikotla, Suryanarayana M. Upadyayula, Venkateswarlu Yenamandra
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Fungi are known to produce a vast array of secondary metabolites that are gaining importance for their biotechnological applications. Screening ofAspergillus gorakhpurensis for the production of bioactive secondary metabolites results in the production of 4-(N-methyl-N-phenyl amino) butan-2-one and itaconic acid. The structure of the known compounds was established by 1H-, 13C-NMR and Mass spectral data. Biological evaluation of the two compounds against test microorganisms showed strong inhibitory activity of 4-(N-methyl-N-phenyl amino) butan-2-one towards bacteria and fungi. Only 4-( N -methyl-N- phenyl amino)-butan-2-one showed a marked significant activity (LD 50 = 330.69 m g/mL ) in Spodoptera litura larvicidal bioassay.

KEYWORDS
  • Aspergillus gorakhpurensis
  • 4-( N -methyl-N- phenyl amino) butan-2-one
  • Itaconic acid
  • Antibacterial
  • Spodoptera litura .