JOURNAL 291


Records of Natural Products
VOLUME & ISSUE
Year: 2010 Issue: 1 January-March
PAGES
p.72 - 78
STATISTICS
Viewed 1869 times.
AUTHORS
    Moses S. Owolabi, Akintayo Ogundajo, Kamil O. Yusuf, Labunmi Lajide, Heather E. Villanueva, Jessika A. Tuten, and William N. Setzer
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


 The essential oil from the dried leaves of Chromolaena odorata (L.) R.M. King & H. Rob. was obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS).  The major components were α-pinene (42.2%), β-pinene (10.6%), germacrene D (9.7%), β-copaen-4α-ol (9.4%), (E)-caryophyllene (5.4%), and geijerene/prejeigerene (7.5%).  The oil was screened for antimicrobial activity and showed antibacterial activity against Bacillus cereus (MIC = 39 μg/mL) and antifungal activity against Aspergillus niger (MIC = 78 μg/mL). DFT (B3LYP/6-31G*) and post-HF (MP2/6-311+G**) indicate that pregeigerene is less stable (0.45 and 3.99 kcal/mol, respectively) than its Cope rearrangement product geigerene.

KEYWORDS
  • Chromolaena odorata
  • Eupatorium odoratum
  • Asteraceae
  • essential oil
  • pinene
  • germacrene D