Chemical Constituents of the Sponge Mycale Sp ecies from South China Sea

 Chemical investigation of the sponge Mycale species from the South China Sea afforded eleven known compounds, henicosanoic acid methyl ester (1) , hexadecyl ethers of glycerol ( 2 ) , N-docosanoyl-D-erythro-(2S,3R)-16-methyl-heptadecasphing-4(E)-enine ( 3 ) , dibutyl phthalate ( 4 ) , cholesterol ( 5 ) , 5α,8α-epidioxycholest-6,22-dien-3β-ol ( 6 ) , 5-hexadecyl-pyrrole-2-carboxaldehyde ( 7 ) , benzoic acid ( 8 ) , 4-hydroxybenzoic acid ( 9 ) , thymine ( 10 ) ,and uracil ( 11 ) . Compounds 1 – 4 , 6 – 9 were obtained from the sponge of the genus Mycale for the first time, and 4 and 6 showed toxicity in the brine shrimp lethality test with the LD 50 values at 2.9 μg/mL and 4. 7 μg/mL, respectively .