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Constituents From the Stem Bark of Cinnamomum zeylanicum Welw. (Lauraceae) and Their Inhibitory Activity Toward Plasmodium falciparum Enoyl-ACP Reductase Enzyme

Original Article

JOURNAL 694

Records of Natural Products
VOLUME & ISSUE
Year: 2013 Issue: 4 October-December
PAGES
p.296 - 301
STATISTICS
Viewed 2270 times.
AUTHORS
    Eric René Sieliatchom Nkanwen, Maurice Ducret Awouafack, Jean Jules Kezetas Bankeu, Hippolyte Kamdem Wabo, Sufyan Awad Alkarim Mustafa, Muhammad Shaiq Ali, Marc Lamshöft, Muhammad Iqbal Choudhary, Michael Spiteller and Pierre Tane
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A trans cinnamic anhydride (1) isolated for the first time from a natural source, along with the known compounds: ferrulic acid (2), (E) p-hydroxy cinnamic acid (3), clovanediol (4), squalene (5), and α -bisabolene (6) were isolated from the stem bark of Cinnamomum zeylanicum. Their structures were elucidated by interpretation of NMR and MS data, and by comparison of these data with those reported in the literature. Their inhibitory properties were evaluated against Plasmodium falciparum enoyl-ACP reductase (PfENR) enzyme. Compounds 1 , 5 and 6 showed moderate inhibitory activity against P. falciparum enoyl-ACP reductase (PfENR) enzyme.

 KEYWORDS
  • Cinnamomum zeylanicum
  • Lauraceae
  • Plasmodium falciparum enoyl-ACP reductase (PfENR) enzyme
  • Antimalarial activity.

SUPPORTING INFORMATION

Supporting Information
Download File 45-RNP-1206-83-supporting.pdf (527.09 KB)