JOURNAL 713


Records of Natural Products
VOLUME & ISSUE
Year: 2014 Issue: 1 January-March
PAGES
p.46 - 50
STATISTICS
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AUTHORS
    Ratchanaporn Chokchaisiri, Prapapan Pimkaew, Pawinee Piyachaturawat, Rattana Chalermglin and Apichart Suksamrarn
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


The present study was aimed to investigate the chemical constituents of Curcuma elata Roxb. (Zingiberaceae) rhizomes originating in Thailand. Ten sesquiterpenes, germacrone (1), curzerenone (2), isofuranodienone (3), furanodienone (4), curdione (5), neocurdione (6), zederone (7), curcumenone (8), 13- hydroxygermacrone (9) and zedoarondiol (10), and four diarylheptanoids, 3-hydroxy- 5-platyphyllone (11), (3S)-1,7-bis(4-hydroxyphenyl)-(6E)-6-hepten-3-ol (12), centrolobol (13) and (3 S )- 1- (3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-(6E)-6-hepten-3-ol (14) were isolated for the first time from the rhizomes of this plant. The structures of the isolated compounds were identified by comparison of the spectroscopic and physical data with those of the reported values and the stereochemistry at the asymmetric carbon was determined by the modified Mosher’s method and, in some cases, was confirmed by comparison of optical rotation data with literature. Compounds 12 and 13 exhibited strong cytotoxic activity against KB cell line, whereas compounds 49and 12-14 showed strong cytoxicity against NCI-H187 cell line.

KEYWORDS
  • Curcuma elata
  • Zingiberaceae
  • sesquiterpenoids
  • diarylheptanoids
  • cytotoxicity . © 2014 ACG Publications. All rights reserved.

SUPPORTING INFORMATION


Supporting Information
Download File 9-RNP-1304-302Supporting information.pdf (1.32 MB)