Secondary Metabolites from Jacaranda mimosifolia and Kigelia africana (Bignoniaceae) and their Anticandidal Activity

Fr om the stem barks of Jacaranda mimosifolia benzoic acid (1), 1-naphthaleneacetic acid, 5-carboxy-1,2,3,4,4a,7,8,8a-octahydro-1,2,4a-trimethyl-[1S-(1α,2β,4aβ,8aα)] (2), betulinic acid (3), lupeol (4) and ursolic acid (5) were isolated. Similarly, lapachol (6), dehydro-α-lapachone (7), 2- acetylfuro-1, 4-naphthoquinone (8), p-coumaric acid (9), caffeic acid (10), nonacosanoic acid, 2-(4-hydroxyphenyl)ethyl ester (11), β-sitosterol (12), kigelinol (13), oleanolic acid (14), β-friedelinol (15), pomolic acid (16), and kojic acid (17) were isolated from the stem barks of Kigelia africana . All the isolated compounds were characterized by using spectroscopic methods especially 1D and 2D NMR and ESI mass spectrometry and comparison with literature data. To the best of our knowledge, compounds 1, 2, 3 and 5, and compounds 11, 14, 15 and 16 were isolated for the first time from Jacaranda mimosifolia and Kigelia africana, respectively. All these compounds were screened for anticandidal activity by agar diffusion method and microbroth dilution technique on four Candida albicans strains (ATCC L26, ATCC12C, ATCCP37039, and ATCCP37037). Among them, compounds 9, 10, and 17 exhibited the highest anticandidal activity that varied between the microbial species (MIC= 0.01 ± 0.00 − 0.03 ± 0.00 mg/mL) on C. albicans ATCC L26, ATCCP37037, ATCCP37039 and ATCC12C strains. Compound 17 was likely the most active against the four Candida albicans strains (MIC= 0.01 ± 0.00 − 0.02 ± 0.00 mg/mL).