JOURNAL 574


Records of Natural Products
VOLUME & ISSUE
Year: 2015 Issue: 4 October-December
PAGES
p.553 - 560
STATISTICS
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AUTHORS
    Taj Ur Rahman, Khanzadi Fatima Khattak, Wajiha Liaqat, Khair Zaman and Syed Ghulam Musharraf
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


The phytochemical examination of the extract of bark of Millettia ovalifolia yielded chemical constituents, which included one novel flavonoid 7-(4-methoxyphenyl)-9H-furo [2, 3-f] chromen-9-one and four new source compounds characterized as 3,7-Dihydroxy-2-phenyl-4H-chromen-4-one, (E)-Ethyl-13-(3,4-dimethoxyphenyl)acrylate, (E)-Methyl-3-(3,4-dimethoxyphenyl)acrylate and N-Ethylacetamide. These compounds were characterized by using advance modern spectroscopic analytical techniques such as UV, IR, 1D, 2D NMR and mass spectrometry. The novel flavonoid (1) displayed significant inhibition of cytosolic form of bovine carbonic anhydrase-II with IC 50 value of 17.86 ± 0.07 µM. This flavonoid may be used as a new pharmacophore to treat cystic fibrosis, glaucoma, epilepsy, leaukomia and other disorders such as neurology etc.

KEYWORDS
  • Millettia ovalifolia bark
  • phytochemicals
  • spectral analysis
  • novel flavonoid
  • bovine carbonic anhydrase inhibition

SUPPORTING INFORMATION


Supporting Information
Download File 68-RNP-1411-228-SI.pdf (1.14 MB)