JOURNAL 616


Records of Natural Products
VOLUME & ISSUE
Year: 2015 Issue: 4 October-December
PAGES
p.586 - 591
STATISTICS
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AUTHORS
    Pooja Srivastava, Jyotshna1, Debabrata Chanda2 and Karuna Shanker
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Pluchea lanceolata (DC.) Oliv. & Hiern (Rasana) is an important medicinal plant due to its usage in number of Ayurvedic formulations. First time, chemical composition of essential oil from the aerial part of P. lanceolata was analyzed by gas chromatography-mass spectrometry (GC-MS) and NMR spectroscopy. Ex-vivo cholinesterase inhibitory activity of the essential oil was also evaluated using mouse brain homogenate. The major components were linalool (32.2%), β-caryophyllene (8.5%), α-terpineol (8.0%), spathulenol (7.4%), linalylacetate (5.6%), naphthalene, 1,6-dimethyl-4-(1-methylethyl)- (4.3%), α-copaene (3.6%), epi-cubebol (3.6%) and trans-α-bergamontene (3.1%). The experimental results showed that hydrodistilate of P. lanceolata significantly inhibited acetylcholinesterase activity (IC 50 value 2.54 ± 0.03 µg/mL).

KEYWORDS
  • Pluchea lanceolata
  • volatile organic contents (VOCs)
  • acetylcholinesterase inhibition
  • GC-MS
  • NMR

SUPPORTING INFORMATION


Supporting Information
Download File 74-RNP-EO_1212-077-SI.pdf (610.34 KB)