JOURNAL 630


Records of Natural Products
VOLUME & ISSUE
Year: 2015 Issue: 4 October-December
PAGES
p.628 - 632
STATISTICS
Viewed 1151 times.
AUTHORS
    Xiang-Rong Tian, Hai-Feng Tang, Yu-Shan Li, Hou-Wen Lin, Xiu-Yun Zhang, Jun-Tao Feng and Xing Zhang
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


The aim of this study was to investigate the chemical constituents of marine bryozoan Cryptosula pallasiana inhabiting Huang Island of China. Three aromatic compounds, p-methylsulfonylmethyl-phenol (1), p-hydroxybenzaldehyde (4) and methylparaben (5), nine alkaloids, 7-bromoquinolin-4(1H)-one (2), 7-bromo-2,4(1H,3H)-quinazolinedione (3), benzamide (6), phenylacetamide (7), 4(3H)-quinazolinone (8), thymine (9), uracil (10), hypoxanthine (11) and tryptophan (12), together with two glycerol derivatives, glycerol (13) and monoheneicosanoin (14), were isolated for the first time from this marine bryozoan. Among the isolates, compounds 1 and 2 were new natural products, and their spectral traits were reported for the first time. The structures of the two compounds were elucidated by extensive spectroscopic analyses, including HR-ESI-MS, EI-MS, 1D- and 2D-NMR techniques. The isolated compounds 1–3 were evaluated for their cytotoxicity against HL-60 human myeloid leukemia cell line. The results showed that bromated alkaloid (3) appeared strong cytotoxicity against HL-60 cells with IC 50 value of 11.87 µg/mL, while compounds 1 and 2 were inactivity.

KEYWORDS
  • Marine bryozoan
  • Cryptosula pallasiana
  • cytotoxicity

SUPPORTING INFORMATION


Supporting Information
Download File 82-RNP-1406-116-SI.pdf (1019.08 KB)